Abstract
Trichostatin A (TSA), an inhibitor of histone deacetylase, has been shown to play an important role in attenuating asthmatic inflammation. However, the effect of TSA in allergic rhinitis is not known. The aims of this study were to investigate the effect of TSA on allergic nasal inflammation and on the induction of regulatory T cells in a murine model of allergic rhinitis. BALB/c mice were sensitized intraperitoneally with ovalbumin (OVA) and then challenged intranasally with OVA. TSA (1 mg/kg) was given to the treatment group, and multiple parameters of allergic responses were evaluated to determine the effects of TSA on allergic rhinitis. Allergic nasal symptom scores, including frequency of rubbing and sneezing, were checked. Eosinophil infiltrations were stained with Chromotrope 2R, and the expression levels of OVA-specific IgE, T-helper 1 (Th1) cytokine (interferon-gamma [IFN-γ]), Th2 cytokines (interleukin [IL] 4 and IL-5) and Treg (Foxp3, IL-10, and transforming growth factor-beta [TGF-β]) were measured by quantitative reverse transcription-polymerase chain reaction or enzyme-linked immunosorbent assay. TSA reduced the scores of allergic nasal symptoms and the amount of eosinophil infiltration into the nasal mucosa. TSA ...Continue Reading
References
Aug 1, 1996·Toxicology Letters·A J Frew
Jun 17, 1999·Allergy·E M VargaS R Durham
Feb 25, 2000·International Archives of Allergy and Immunology·H Yssel, H Groux
Jan 3, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·J J ShimJ A Nadel
Aug 25, 2001·American Journal of Respiratory and Critical Care Medicine·A SutoI Iwamoto
Nov 7, 2001·The Journal of Experimental Medicine·M A Curotto de LafailleJ J Lafaille
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Flavio LeoniPaolo Mascagni
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zeina JaffarKevan Roberts
Jun 3, 2004·The Journal of Experimental Medicine·Mübeccel AkdisCezmi A Akdis
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael StassenEdgar Schmitt
Aug 5, 2004·Allergy·P W Hellings, J L Ceuppens
Jan 15, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J-H ChoiD-Y Kim
Mar 2, 2005·The European Respiratory Journal·P J BarnesK Ito
Dec 5, 2006·BMC Pulmonary Medicine·Peter K Jeffery, Tari Haahtela
Aug 19, 2007·Oncogene·W S XuP A Marks
Feb 1, 2008·The Journal of Allergy and Clinical Immunology·Pankaj BhavsarIan M Adcock
Nov 13, 2008·The Journal of Experimental Medicine·Flurina MeilerMübeccel Akdis
Aug 8, 2009·European Journal of Immunology·Shimon SakaguchiTomoyuki Yamaguchi
Jan 14, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J-S ChoH-M Lee
May 10, 2012·Current Opinion in Otolaryngology & Head and Neck Surgery·Thuy-Anh N Melvin, Murugappan Ramanathan
Jul 11, 2012·Cellular Immunology·Xuming GuoZhiqiang Pan
Feb 15, 2013·American Journal of Rhinology & Allergy·Jung-Sun ChoHeung-Man Lee
Apr 26, 2013·Frontiers in Pharmacology·Samantha S PossaIolanda F L C Tibério
Citations
Apr 8, 2020·Frontiers in Pharmacology·Saisai WangWeifen Zhang
Nov 9, 2018·Frontiers in Immunology·Dylan KrajewskiClinton B Mathias
May 15, 2020·Clinical and Experimental Otorhinolaryngology·Ki-Il LeeJi-Hun Mo
Jun 8, 2021·Frontiers in Immunology·Siti Muhamad Nur HusnaKah Keng Wong
Jan 25, 2020·Brazilian Journal of Otorhinolaryngology·Yun-Xiu WangZhi-Wei Cao