PMID: 11605898Oct 19, 2001Paper

Antiallodynic effect of intrathecal neostigmine is mediated by spinal nitric oxide in a rat model of diabetic neuropathic pain

Anesthesiology
S R ChenH L Pan

Abstract

Intrathecal administration of acetylcholinesterase inhibitors produces antinociception in both animals and humans, but their effect on diabetic neuropathic pain has not been studied. In the current study, we determined the antiallodynic effect of intrathecal injection of an acetylcholinesterase inhibitor, neostigmine, in a rat model of diabetic neuropathic pain. In addition, since acetylcholine can increase release of nitric oxide in the spinal cord, we studied the role of spinal endogenous nitric oxide in the action of intrathecal neostigmine in diabetic neuropathic pain. Rats were rendered diabetic with an intraperitoneal 50-mg/kg injection of streptozotocin. Intrathecal catheters were inserted, with tips in the lumbar intrathecal space. Mechanical allodynia was determined by application of von Frey filaments to the hind paw. We first determined the dose-dependent effect of intrathecal neostigmine on allodynia. The role of spinal nitric oxide in the action of intrathecal neostigmine was then examined through intrathecal treatments with a neuronal nitric oxide synthase inhibitor (TRIM), a nitric oxide scavenger (PTIO), L-arginine, or D-arginine. The diabetic rats developed a sustained tactile allodynia within 4 weeks after str...Continue Reading

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Citations

Aug 26, 2003·Advanced Drug Delivery Reviews·Carolyn A Fairbanks
Sep 10, 2015·Drug Development Research·Claudia Ivonne Araiza-SaldañaVinicio Granados-Soto
Jan 19, 2010·European Journal of Pharmacology·Claudia I Araiza-SaldañaVinicio Granados-Soto
Jun 5, 2007·Neuropharmacology·Philip G Jones, John Dunlop
Aug 11, 2006·Pharmacology, Biochemistry, and Behavior·Deysi Y Bermúdez-OcañaVinicio Granados-Soto
Jan 28, 2006·European Journal of Pharmacology·Teresa Mixcoatl-ZecuatlVinicio Granados-Soto
Aug 31, 2011·Nitric Oxide : Biology and Chemistry·Thiago R L RomeroIgor D G Duarte
Jul 5, 2011·Nitric Oxide : Biology and Chemistry·Yara CurySergio Henrique Ferreira
Jun 28, 2008·Pharmacology, Biochemistry, and Behavior·Francisca Pérez-SeverianoVinicio Granados-Soto
Oct 9, 2008·The Journal of Physiological Sciences : JPS·Ha Neul KimByung-Il Min
Oct 22, 2010·International Journal of Radiation Biology·János F LászlóRóbert Pórszász
Jul 2, 2019·The International Journal of Neuroscience·Renuka VermaAmteshwar Singh Jaggi
Sep 11, 2003·The Journal of Pharmacology and Experimental Therapeutics·Shao-Rui Chen, Hui-Lin Pan
Nov 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Ghous M KhanHui-Lin Pan

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