PMID: 8953421Nov 1, 1996Paper

Antianaphylactic activity of Poncirus trifoliata fruit extract

Journal of Ethnopharmacology
Y M LeeH M Kim

Abstract

The effect of an aqueous extract of Poncirus trifoliata (L.) Raf. (Rutaceae) fruits (PTFE) on compound 48/80-induced mortality associated with anaphylaxis was studied in rats. PTFE inhibited compound 48/80-induced anaphylaxis 100% with a dose of 1.6 mg/g body weight (BW) 1 h before or 5 min after injection of compound 48/80. PTFE inhibited compound 48/80-induced anaphylaxis almost 100% with doses above 0.4 mg/g BW intraperitoneally administered. PTFE (1-1000 micrograms/ml) also dose-dependently inhibited the histamine release induced by compound 48/80 (5 micrograms/ml) in rat peritoneal mast cells. The level of cAMP in peritoneal mast cells, when PTFE was added, increased transiently, and significantly increased 53-fold at 10 s compared with that of basal cells. Moreover, PTFE inhibited intracellular calcium release induced by compound 48/80. These results suggest that PTFE has antianaphylactic activity by stabilizing the peritoneal mast cell membrane.

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Citations

Sep 3, 1999·Journal of Ethnopharmacology·T Y ShinH M Kim
Jan 5, 2000·Journal of Ethnopharmacology·H M KimT Y Shin
Sep 3, 1999·Journal of Ethnopharmacology·H M KimS T Park
Jul 16, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ho-Jeong NaHyung-Min Kim
Mar 8, 2011·Chinese Medicine·Jiyoung YeoMyeong-Ho Jung
Aug 2, 2007·Chemical & Pharmaceutical Bulletin·Ah-Reum HanEun-Kyoung Seo
Jun 16, 2012·Indian Journal of Pharmacology·Rakesh Sagar, H B Sahoo
Dec 8, 2009·Journal of Ethnopharmacology·Keun Han ChoiKyu Yong Jung
Jan 9, 2003·The American Journal of Medicine·Gary B Zuckerman, Leonard Bielory
Oct 28, 2009·European Journal of Pharmacology·Eun Myoung ShinYeong Shik Kim
Apr 1, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Tae-Yong ShinSang-Hyun Kim
Sep 30, 2005·Journal of Ethnopharmacology·Hyun-Tai LeeChang-Koo Shim
Mar 26, 2015·Laboratory animal research·Dong-Jun YuTae-Wan Kim
Jul 27, 2018·The Journal of Microbiology·Yoonki HeoYoung Bong Kim
May 16, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Y M LeeH M Kim
Sep 12, 2002·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S O Okpo, O O Adeyemi
Mar 31, 2009·Journal of Ethnopharmacology·Jessy E MathewAlex Joseph

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.