PMID: 6412966Sep 5, 1983Paper

Antianaphylactic effect of naloxone in mice is mediated by increased central sympathetic outflow to sympathetic nerve endings and adrenal medulla

Brain Research
S Amir

Abstract

Intravenous naloxone, 1 or 10 mg/kg, protects sensitized mice from lethal anaphylaxis. The protective effect is reversed by pretreatment with the ganglionic blocker, chlorisondamine chloride, peripheral chemical sympathectomy with 6-hydroxydopamine or bilateral adrenal gland denervation. The possible involvement of the sympathetic nervous system in naloxone's antianaphylactic action, suggested by these findings, is discussed.

References

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Citations

Mar 11, 1985·Brain Research·S Amir, J M van Ree
Mar 1, 1984·Pharmacology, Biochemistry, and Behavior·S Amir
Jan 1, 1989·Annals of the New York Academy of Sciences·J W HoladayN J Gurll
Jul 1, 1986·Resuscitation·W G BarsanS A Syverud
Jan 1, 1988·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·J D WatsonC J Hinds

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.