PMID: 11920723Mar 29, 2002Paper

Antiandrogen blocks estrogen-induced masculinization of the song system in female zebra finches

Journal of Neurobiology
William GrishamArthur P Arnold

Abstract

Song behavior and the neural song system that serves it are sexually dimorphic in zebra finches. In this species, males sing and females normally do not. The sex differences in the song system include sex differences in the proportion of neurons that express androgen receptors, which is higher in specific brain regions of males. Estradiol (E2) administered in early development profoundly masculinizes the song system of females, including the proportion of neurons expressing androgen receptors. We examined whether or not the expression of these androgen receptors was causally related to the E2-induced masculinization of this system by co-administering Flutamide, which blocks androgen action at the receptor, along with E2 at hatching. E2 alone had its usual masculinizing effect on the female song system, measured in adulthood: increasing the size of song nuclei, the size of neurons in HVC, RA, and 1MAN, and the number of neurons in HVC. E2's masculinizing action, however, was significantly diminished on all measures by co-administering Flutamide. Indeed, females receiving both E2 and Flutamide were never significantly more masculine than controls on any measure. Flutamide alone had no effect. Our results strongly suggest that the...Continue Reading

References

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Citations

Dec 10, 2003·Current Opinion in Neurobiology·Arthur P Arnold
Aug 29, 2006·Endocrinology·Sarah E LondonBarney A Schlinger
May 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Xuqi ChenArthur P Arnold
Feb 3, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Juli Wade
Sep 16, 2008·Neuroscience Letters·William GrishamArthur P Arnold
Apr 3, 2007·Neuroscience Letters·William GrishamArthur P Arnold
Aug 18, 2004·Annals of the New York Academy of Sciences·Juli Wade, Arthur P Arnold
Feb 1, 2015·Frontiers in Neuroendocrinology·Amanda A Krentzel, Luke Remage-Healey
Nov 19, 2003·The Journal of Comparative Neurology·Sarah E LondonBarney A Schlinger
Feb 3, 2004·The Journal of Comparative Neurology·Yong-Hwan KimArthur P Arnold
Jan 1, 2003·The Journal of Comparative Neurology·William R PerlmanArthur P Arnold
Mar 31, 2007·The Journal of Comparative Neurology·Sarah E London, Barney A Schlinger
Apr 26, 2005·Journal of Neurobiology·Juli WadeRobert J Tempelman
Sep 14, 2006·Journal of Applied Microbiology·S V RavvaL H Stanker
Dec 20, 2008·Canadian Journal of Microbiology·Julie KinzelmanGerald Sedmak

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