PMID: 9423292Jan 10, 1998Paper

Antiandrogenic phenolic constituents from Dalbergia cochinchinensis

Phytochemistry
Vibha PathakM Satake

Abstract

Four new compounds, 9-hydroxy-6,7-dimethoxydalbergiquinol, 6-hydroxy-2,7-dimethoxyneoflavene, 6,4'-dihydroxy-7-methoxyflavan and 2,2',5-trihydroxy-4-methoxybenzophenone, in addition to eight known phenolic compounds including 7-hydroxy-6-methoxyflavone, have been isolated from the stems of Dalbergia cochinchinensis. Their structures were established by spectroscopic techniques including one- and two-dimensional NMR methods. The first two compounds showed potent inhibitory activity towards 5 alpha-dihydrotestosterone (DHT) which binds with an androgen receptor to form a DHT-receptor complex that causes androgen-dependent disease.

References

Apr 1, 1973·The Journal of Endocrinology·K D Bingham, D A Shaw
Mar 1, 1994·Journal of Natural Products·M SauvainJ Poisson

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Citations

Sep 8, 2010·Journal of Natural Medicines·Yukiko MatsuoYoshihiro Mimaki
Oct 1, 2017·Chemistry & Biodiversity·Xiao-Pan MaWei-Dong Pan
May 5, 2012·Angewandte Chemie·Jennifer M FinefieldRobert M Williams
Nov 13, 2019·Natural Product Research·Le Thi Hong NhungNguyen Thi Hoang Anh

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