Antiandrogenic properties of spironolactone. Clinical trial in the management of female hirsutism

Journal of Endocrinological Investigation
M MessinaG M Molinatti

Abstract

The effect of spironolactone on female hirsutism was studied in 18 patients. The drug was administered at the dose of 400 mg for the first ten days and 300-200 mg later on in a first group of women (Group A); a second group (Group B) was given 200 mg spironolactone for the whole length of therapy. A significant decrease of the index of Ferriman and Gallwey (p = 0.01) was noted from the 100th day of treatment; acne and seborrhoea improved concomitantly. Plasma total testosterone values fell from 0.64 +/- 0.24 ng/ml to 0.32 +/- 0.12 ng/ml (p = 0.002) during the first 5 days only in the patients of Group A; in the other patients no significant changes were observed. PRL did not significantly change from pretreatment values; FSH and LH values at the 5th, 10th, and 15th day of therapy did not show a uniform course in both groups. On the basis of these results spironolactone administration appears promising in the therapy of female hirsutism.

References

Feb 1, 1978·The Journal of Clinical Endocrinology and Metabolism·S M RifkaD L Loriaux
Sep 1, 1978·The Journal of Clinical Endocrinology and Metabolism·H P Schane, G O Potts
Jun 1, 1975·Journal of Steroid Biochemistry·J HammersteinF Zielske
Nov 1, 1978·Clinical Endocrinology·M J TiddR F Palmer
Sep 1, 1979·Fertility and Sterility·A Boisselle, R R Tremblay
Jun 1, 1977·The Journal of Clinical Endocrinology and Metabolism·U AbshagenW Oelkers
Aug 1, 1977·The Journal of Clinical Endocrinology and Metabolism·R Caminos-TorresP J Snyder
Dec 1, 1976·The Journal of Clinical Endocrinology and Metabolism·R J SantenJ Friend
Dec 29, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·U AbshagenG Luszpinski
Oct 1, 1975·The Journal of Clinical Endocrinology and Metabolism·B StrippR H Menard
Apr 18, 1969·Deutsche medizinische Wochenschrift·J Hammerstein, B Cupceancu
Mar 1, 1980·The Journal of Endocrinology·J LevyS M Glick
Sep 1, 1980·The Journal of Clinical Endocrinology and Metabolism·G Shapiro, S Evron
Nov 1, 1961·The Journal of Clinical Endocrinology and Metabolism·D FERRIMAN, J D GALLWEY

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Citations

Dec 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wilfried RozhonBrigitte Poppenberger
Jul 1, 1989·Postgraduate Medical Journal·A R McLellanG T McInnes
Jan 1, 1988·The Australasian Journal of Dermatology·A W Callan
Dec 1, 1989·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·J PrezeljL Andolsek
Apr 1, 1985·The Australasian Journal of Dermatology·A K ThomasG Jerums
Aug 1, 1986·The British Journal of Dermatology·M F MuhlemannP Wise
Aug 1, 1986·Journal of the Royal Society of Medicine·D J Evans, C W Burke
Feb 6, 2017·American Journal of Clinical Dermatology·Alison M LaytonEsther J van Zuuren
Apr 14, 2016·Journal of Endocrinological Investigation·C SabbadinD Armanini
Nov 1, 1991·International Journal of Dermatology·G NotoM Aricó
Dec 1, 1993·Journal of Endocrinological Investigation·G R McMullen, A J Van Herle
Aug 1, 1985·Clinical Endocrinology·P Dorrington-WardP Wise
Dec 18, 1998·Journal of Endocrinological Investigation·E Diamanti-Kandarakis
Mar 1, 1986·Annals of Clinical Biochemistry·A A IsmailM J Wheeler
Nov 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·F SciarraF Di Silverio
Oct 1, 1988·Clinics in Dermatology·R S Rittmaster

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