Antianginal efficacy of carvedilol, a beta-blocking drug with vasodilating activity

The American Journal of Cardiology
E A RodriguesE B Raftery

Abstract

The efficacy of carvedilol, a new vasodilating beta-blocking drug, was evaluated in 20 patients with chronic angina using a single-blind, placebo-controlled protocol. A 2-week placebo phase was followed by therapy with carvedilol, 25 mg twice daily for 2 weeks, after which the dose was doubled. There was then a second placebo phase lasting 2 weeks. Treadmill exercise testing, 24-hour ambulatory electrocardiographic monitoring and drug blood level assays were performed at the end of each phase. Exercise time (mean +/- standard error of mean) increased from 7.4 +/- 0.5 minutes during placebo to 9.0 +/- 0.5 minutes carvedilol, 25 mg twice daily (p less than 0.001), and to 9.2 +/- 0.4 minutes with 50 mg twice daily (p less than 0.001). Mean time to 1 mm of ST depression in both bipolar leads CM5 and CC5 increased significantly, but peak ST depression did not change. Heart rate at rest was reduced at both dose levels, from 86 +/- 4 beats/min during placebo to 70 +/- 2 beats/min with 25 mg twice daily (p less than 0.001) and to 67 +/- 3 beats/min with 50 mg twice daily (p less than 0.001). Systolic blood pressure at rest was significantly reduced at both doses (p less than 0.05; p less than 0.01), but blood pressure during exercise w...Continue Reading

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Citations

Jan 1, 1992·European Journal of Clinical Pharmacology·B K KrämerT Risler
Nov 1, 1990·The American Journal of Cardiology·P Das GuptaA Lahiri
Mar 30, 2016·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Pyung Chun OhEak Kyun Shin
Jan 24, 2014·Nursing Research and Practice·Jeffrey W Young, Sheila Melander
Apr 16, 1998·Scandinavian Cardiovascular Journal. Supplement·L Hansson, A Himmelmann
Oct 16, 2012·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Carol Chen-ScarabelliTiziano M Scarabelli

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