Antiangiogeneic Strategies in Mesothelioma

Frontiers in Oncology
Anna K NowakGérard Zalcman

Abstract

There is a strong rationale for inhibiting angiogenesis in mesothelioma. Vascular endothelial growth factor (VEGF) is an autocrine growth factor in mesothelioma and a potent mitogen for mesothelial cells. Further, the abnormal tumor vasculature promotes raised interstitial pressure and hypoxia, which may be detrimental to both penetration and efficacy of anticancer agents. Antiangiogenic agents have been trialed in mesothelioma for close to two decades, with early phase clinical trials testing vascular targeting agents, the VEGF-A targeting monoclonal antibody bevacizumab, and numerous tyrosine kinase inhibitors, many with multiple targets. None of these have shown efficacy which has warranted further development as single agents in any line of therapy. Whilst a randomized phase II trial combining the multitargeted tyrosine kinase inhibitor nintedanib with platinum/pemetrexed chemotherapy was positive, these results were not confirmed in a subsequent phase III study. The combination of cisplatin and pemetrexed with bevacizumab, in appropriately selected patients, remains the only anti-angiogenic combination showing efficacy in mesothelioma. Extensive efforts to identify biomarkers of response have not yet been successful.

References

Aug 4, 1999·Virchows Archiv : an International Journal of Pathology·J E KönigK M Müller
Aug 19, 1999·The Journal of Pathology·S Kumar-SinghE Van Marck
Oct 8, 1999·The Journal of Clinical Investigation·T OstendorfJ Floege
Mar 8, 2000·Respiration; International Review of Thoracic Diseases·J KönigK Müller
Jun 6, 2000·Critical Reviews in Oncology/hematology·P GerwinsL Claesson-Welsh
Feb 21, 2003·International Journal of Cancer. Journal International Du Cancer·Rizwan MasoodParkash S Gill
May 3, 2003·Cancer Cell·Selma PennacchiettiPaolo M Comoglio
Jul 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicholas J VogelzangPaolo Paoletti
Apr 15, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Paul BaasNico van Zandwijk
Jun 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Guangbin XiaParkash S Gill
Aug 2, 2005·Lancet·Bruce W S RobinsonRichard A Lake
Aug 25, 2005·Journal of Surgical Oncology·Frank A ScappaticciHerbert Hurwitz
Sep 20, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A KlabatsaD A Fennell
Oct 5, 2006·Endocrine, Metabolic & Immune Disorders Drug Targets·Girolamo RanieriGiampietro Gasparini
Jan 31, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Xiaolei ZhuChirag R Parikh
Jun 15, 2007·Microvascular Research·Dai Fukumura, Rakesh K Jain
Aug 10, 2007·Journal of the National Cancer Institute·Frank A ScappaticciHerbert Hurwitz
Oct 4, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P TappendenC Carroll
Jun 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sergei KusmartsevJohannes Vieweg
Jan 20, 2010·Journal of Cellular and Molecular Medicine·Yi Wang, Michael Ohh
Apr 22, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vanesa GregorcClaudio Bordignon
Jun 12, 2010·Journal of the American Society of Nephrology : JASN·Shenhong WuXiaolei Zhu
Sep 4, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Giovanni GiulianiStefan Walzer
Aug 26, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sarita DubeyHedy Lee Kindler
Mar 23, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Herbert I HurwitzUlrich-Peter Rohr
Oct 4, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Linda L GarlandDavid R Gandara
Oct 19, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Scott A LaurieLesley Seymour
Dec 27, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Thierry JahanHedy Lee Kindler

❮ Previous
Next ❯

Citations

Sep 5, 2020·International Journal of Molecular Sciences·Ece Cakiroglu, Serif Senturk
Mar 7, 2021·Cells·Maksymilian ZiajaAgnieszka Wanda Piastowska-Ciesielska

❮ Previous
Next ❯

Methods Mentioned

BETA
xenografts
xenograft
biopsies
ELISA
nuclear translocation

Software Mentioned

LUME

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Thorax
R RuddM F Muers
Annals of Oncology : Official Journal of the European Society for Medical Oncology
W Weder
Medit︠s︡inskai︠a︡ sestra
Iu L Rozanov
Medizinische Monatsschrift
V Misgeld
The Medical Journal of Australia
B Gandevia
© 2021 Meta ULC. All rights reserved