PMID: 24367160Jan 1, 2009Paper

Antiangiogenesis immunotherapy induces epitope spreading to Her-2/neu resulting in breast tumor immunoediting

Breast Cancer : Targets and Therapy
Matthew Seavey, Yvonne Paterson

Abstract

Targeting tumors using cancer vaccine therapeutics has several advantages including the induction of long-term immunity, prime boost strategies for additional treatments and reduced side effects compared to conventional chemotherapeutics. However, one problem in targeting tumor antigens directly is that this can lead to antigen loss or immunoediting. We hypothesized that directing the immune response to a normal cell type required for tumor growth and survival could provide a more stable immunotherapeutic target. We thus examined the ability of an antiangiogenesis, Listeria monocytogenes (Lm)-based vector to deliver extracellular and intracellular fragments of the mouse vascular endothelial growth factor receptor-2/Flk-1 molecule, Lm-LLO-Flk-E1, and Lm-LLO-Flk-11 respectively, in an autochthonous model for Her-2/neu(+) breast cancer. We found that these vaccines could cause epitope spreading to the endogenous tumor protein Her-2/neu and significantly delay tumor onset. However, tumors that grew out overtime accumulated mutations in the Her-2/neu molecule near or within cytotoxic T lymphocytes epitopes. We show here for the first time how an antiangiogenesis immunotherapy can be used to delay the onset of a spontaneous tumor thr...Continue Reading

Citations

Jul 30, 2015·Computer Methods and Programs in Biomedicine·Elpiniki I PapageorgiouNikolaos Papandrianos
Nov 26, 2013·Best Practice & Research. Clinical Anaesthesiology·Caroline P LeErica K Sloan
May 27, 2014·Frontiers in Cellular and Infection Microbiology·Laurence M Wood, Yvonne Paterson

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