Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer.

Cancer Research
Rajeev K ShrimaliSteven A Rosenberg

Abstract

Adoptive cell transfer (ACT)-based immunotherapies can mediate objective cancer regression in animal models and in up to 70% of patients with metastatic melanoma; however, it remains unclear whether the tumor vasculature impedes the egress of tumor-specific T cells, thus hindering this immunotherapy. Disruption of the proangiogenic interaction of vascular endothelial growth factor (VEGF) with its receptor (VEGFR-2) has been reported to "normalize" tumor vasculature, enhancing the efficacy of chemotherapeutic agents by increasing their delivery to the tumor intersitium. We thus sought to determine whether disrupting VEGF/VEGFR-2 signaling could enhance the effectiveness of ACT in a murine cancer model. The administration of an antibody against mouse VEGF synergized with ACT to enhance inhibition of established, vascularized, B16 melanoma (P = 0.009) and improve survival (P = 0.003). Additive effects of an antibody against VEGFR-2 in conjunction with ACT were seen in this model (P = 0.013). Anti-VEGF, but not anti-VEGFR-2, antibody significantly increased infiltration of transferred cells into the tumor. Thus, normalization of tumor vasculature through disruption of the VEGF/VEGFR-2 axis can increase extravasation of adoptively t...Continue Reading

References

Jul 11, 2001·Immunologic Research·J E Ohm, D P Carbone
Aug 20, 2003·The Journal of Experimental Medicine·Willem W OverwijkNicholas P Restifo
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Jan 13, 2006·Nature Clinical Practice. Oncology·Rakesh K JainJay S Loeffler
Jan 18, 2006·Annual Review of Medicine·Judah Folkman
Apr 4, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anita E M DirkxArjan W Griffioen
Sep 2, 2006·Science·Richard A MorganSteven A Rosenberg
Nov 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Betty LiKarin Jooss
Mar 22, 2007·Expert Opinion on Biological Therapy·Benjamin F JohnsonMichael A Morse
Jul 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elizabeth A ManningLeisha A Emens
Jan 15, 2008·Cancer Immunology, Immunotherapy : CII·Takuya OsadaMichael A Morse
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Steven A Rosenberg
Sep 4, 2008·Cell and Tissue Research·Yongping Crawford, Napoleone Ferrara
Sep 24, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark E DudleySteven A Rosenberg
Mar 24, 2009·Current Opinion in Immunology·Steven A Rosenberg, Mark E Dudley

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Citations

Apr 12, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Agata MatejukClaudine Kieda
Apr 25, 2012·Cancer Immunology, Immunotherapy : CII·Dyana K Dalton, Randolph J Noelle
Apr 11, 2012·Cancer Immunology, Immunotherapy : CII·Gwendoline Rahir, Muriel Moser
Jun 12, 2012·Cancer Immunology, Immunotherapy : CII·Anna WasiukRandolph J Noelle
Oct 7, 2010·International Journal of Clinical Oncology·Nobuyoshi Hiraoka
Feb 8, 2011·Cancer Metastasis Reviews·Lana E KandalaftGeorge Coukos
Jun 19, 2012·Cancer Metastasis Reviews·Koichi ItoStephen J Ralph
Mar 23, 2012·Nature Reviews. Cancer·Matthew Vanneman, Glenn Dranoff
Jun 2, 2011·Nature Reviews. Drug Discovery·Peter Carmeliet, Rakesh K Jain
Feb 4, 2012·Nature Reviews. Drug Discovery·Lorenzo GalluzziGuido Kroemer
May 2, 2012·Proceedings of the National Academy of Sciences of the United States of America·Anna JohanssonRuth Ganss
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yuhui HuangMark C Poznansky
Mar 7, 2012·Cold Spring Harbor Perspectives in Medicine·Shom GoelRakesh K Jain
Jul 12, 2011·Physiological Reviews·Shom GoelRakesh K Jain
Apr 13, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ryan S TurleyDouglas S Tyler
May 30, 2012·Journal of Translational Medicine·Ivan Martinez ForeroIgnacio Melero
Jun 20, 2013·Journal of Translational Medicine·Lana E KandalaftGeorge Coukos
Dec 1, 2012·Immunotherapy·Sunitha KakarlaStephen Gottschalk
Mar 15, 2011·Immunotherapy·K H Chow, Stephen Gottschalk
Oct 15, 2011·Immunotherapy·Devin B Lowe, Walter J Storkus
Oct 31, 2013·Trends in Molecular Medicine·Anna JohanssonRuth Ganss
Nov 10, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A G Duffy, T F Greten
Sep 6, 2014·Neuro-oncology·David A ReardonGlenn Dranoff
Feb 27, 2013·Cancer Research·Yuhui HuangRakesh K Jain
Oct 27, 2011·Médecine sciences : M/S·Eric TartourWolf H Fridman
Nov 16, 2011·Melanoma Research·Travis E GrotzSvetomir N Markovic
Dec 17, 2015·Nature Reviews. Clinical Oncology·Peter SavasSherene Loi
Apr 14, 2015·Seminars in Cancer Biology·W G JiangD Santini
Jan 19, 2016·Nature Reviews. Drug Discovery·Napoleone Ferrara, Anthony P Adamis
Apr 4, 2015·Science·Johanna A Joyce, Douglas T Fearon
Oct 29, 2010·Expert Opinion on Biological Therapy·Kewal K Jain
Feb 14, 2016·Seminars in Immunology·Ainhoa ArinaVincenzo Bronte
Jan 15, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Stéphane ChampiatJean-Charles Soria
Aug 5, 2015·Biochimica Et Biophysica Acta·Eran OphirLana E Kandalaft
Jun 15, 2015·Biochimica Et Biophysica Acta·Anna JohanssonRuth Ganss
Jan 19, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhong-Yi DongYi-Long Wu
May 9, 2012·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Esther A KleibeukerVictor L Thijssen
May 19, 2012·Biomaterials·Matthias T StephanDarrell J Irvine

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