Antiangiogenic gene therapy of cancer: recent developments

Journal of Translational Medicine
Anita TandleSteven K Libutti

Abstract

With the role of angiogenesis in tumor growth and progression firmly established, considerable effort has been directed to antiangiogenic therapy as a new modality to treat human cancers. Antiangiogenic agents have recently received much widespread attention but strategies for their optimal use are still being developed. Gene therapy represents an attractive alternative to recombinant protein administration for several reasons. This review evaluates the potential advantages of gene transfer for antiangiogenic cancer therapy and describes preclinical gene transfer work with endogenous angiogenesis inhibitors demonstrating the feasibility of effectively suppressing and even eradicating tumors in animal models. Additionally, we describe the advantages and disadvantages of currently available gene transfer vectors and update novel developments in this field. In conclusion, gene therapy holds great promise in advancing antiangiogenesis as an effective cancer therapy and will undoubtedly be evaluated in human clinical trials in the near future.

References

May 16, 1990·Journal of the National Cancer Institute·R J SharpeT E Maione
Jan 23, 1987·Science·J Folkman, M Klagsbrun
Jan 1, 1987·Nouvelle Revue Française D'hématologie·A Camez, G Tobelem
Sep 1, 1987·Annals of Surgery·J Folkman, D E Ingber
Apr 5, 1989·Journal of the National Cancer Institute·H F Dvorak, I Gresser
Nov 18, 1971·The New England Journal of Medicine·J Folkman
Aug 12, 1971·The New England Journal of Medicine·J Folkman
Apr 19, 1995·Journal of the National Cancer Institute·E E VoestJ Folkman
Jan 1, 1994·Cold Spring Harbor Symposia on Quantitative Biology·M S O'ReillyJ Folkman
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·R K SinghI J Fidler
Oct 1, 1994·Molecular Biotechnology·D S Latchman
Oct 1, 1993·The Journal of Experimental Medicine·M J BrundaM K Gately
Jun 1, 1996·Nature Medicine·M S O'ReillyJ Folkman
Jun 1, 1996·Seminars in Cancer Biology·J F Marshall, I R Hart
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·M CarusoS H Chen
Jun 1, 1997·Nature Biotechnology·R PasqualiniE Ruoslahti
Jul 1, 1997·Nature Biotechnology·N S TempletonG N Pavlakis
Nov 14, 1997·Nature Medicine·M SkobeN E Fusenig
Apr 29, 1998·The Journal of Clinical Investigation·G ThurstonD M McDonald
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·P LinK G Peters
Mar 2, 1999·Biochemical and Biophysical Research Communications·R RamchandranV P Sukhatme
Mar 2, 1999·Journal of the National Cancer Institute·T MäkitieT Kivelä
Mar 30, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D LaroccaA Baird
May 18, 1999·Journal of Molecular Biology·M A Poul, J D Marks
Aug 3, 1999·Nature Biotechnology·J Folkman
Aug 3, 1999·Nature Biotechnology·E KoivunenR Pasqualini

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Citations

Jun 28, 2011·Cancer Chemotherapy and Pharmacology·Xing-Chen PengJi-Yan Liu
May 3, 2005·Nature Reviews. Drug Discovery·Mads Hald AndersenPer thor Straten
May 26, 2007·Applied Immunohistochemistry & Molecular Morphology : AIMM·Fabio GrizziNicola Dioguardi
Dec 5, 2012·BMC Complementary and Alternative Medicine·Jin-Mu YiNo Soo Kim
Apr 23, 2008·Pediatric Research·Fabio GrizziAntonio Di Ieva
Sep 15, 2007·Medicinski pregled·Ivana UrosevićStevan Popović
Apr 12, 2006·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Bela BalintMiroljub Trkuljić
Jul 26, 2012·Journal of Signal Transduction·Valentina CeaChiara Verpelli
Sep 25, 2014·BMC Complementary and Alternative Medicine·Jin-Mu YiNo Soo Kim
Oct 28, 2008·Neurological Research·Necmettin TanrioverCengiz Kuday
Jul 10, 2010·Journal of Biomedicine & Biotechnology·Mads Hald AndersenPer Thor Straten
Jul 23, 2016·Viruses·Pravinkumar PurushothamanSubhash C Verma
Apr 26, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Barbara GeusensJo Lambert
Feb 20, 2007·Molecular Aspects of Medicine·Luca PersanoStefano Indraccolo
Jul 21, 2005·Technology in Cancer Research & Treatment·Paxton V DicksonAndrew M Davidoff
Mar 25, 2006·Future Oncology·John Y Dong, Jan Woraratanadharm
May 29, 2008·Cancer Metastasis Reviews·Dominique JenningsRobert J Gillies
Sep 9, 2006·Molecular Endocrinology·David PiwnicaVincent Goffin
Jan 12, 2008·World Journal of Gastroenterology : WJG·Nima KhalighinejadAmir Momeni
Dec 18, 2008·Cancer·Anita TandleSteven K Libutti
Jul 30, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Manjunath B JoshiThérèse J Resink
Nov 18, 2014·World Journal of Gastroenterology : WJG·Mohamed HassanMosaad Megahed
Dec 24, 2005·Blood·Yanzheng Liu, Albert Deisseroth
Jan 16, 2020·International Journal of Molecular Sciences·Anubhab MukherjeeSudip Mukherjee
Feb 21, 2006·World Journal of Gastroenterology : WJG·Andreas P Sutter, Henry Fechner
Apr 23, 2020·Indian Journal of Pathology & Microbiology·Muhammad Shahidan Muhammad SakriHasnan Jaafar
Jun 24, 2006·Journal of Leukocyte Biology·Birgit SchaffhauserGerhard Christofori
Dec 26, 2018·International Journal of Molecular Sciences·Rosanna VillaniGaetano Serviddio
Nov 17, 2006·World Journal of Gastroenterology : WJG·Ching-Chiu LiuMarie C M Lin

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Methods Mentioned

BETA
xenografts
xenograft
transfection
Antisense
antisense oligonucleotides
phage display

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