Antiangiogenic photodynamic therapy with targeted liposomes

Methods in Enzymology
Naoto Oku, Takayuki Ishii

Abstract

Antiangiogenic photodynamic therapy (PDT) is a promising modality for cancer treatment, since it causes efficient cutoff of oxygen and nutrients to the tumor cells and thus indirectly eradicates the tumor cells. For the improvement of therapeutic efficacy of antiangiogenic PDT by using a photosensitizer benzoporphyrin derivative monoacid ring A (BPD-MA) in a liposomal formulation, we endowed the liposomes with an active-targeting probe, Ala-Pro-Arg-Pro-Gly (APRPG), a peptide specific for angiogenic endothelial cells. APRPG-PEG-modified liposomal BPD-MA (APRPG-PEG-LipBPD-MA) accumulated in tumor tissues to a similar extent as PEG-LipBPD-MA at 3-h postinjection. In contrast, APRPG-PEG-LipBPD-MA strongly suppressed tumor growth by PDT treatment, but PEG-LipBPD-MA did not. This finding suggests that antiangiogenic PDT with targeted liposomes is an efficient modality for tumor treatment, whereas PEG-modified nontargeted liposomes are not suitable as a carrier of photosensitizers. The reason for the observed ineffectiveness of PEG-LipBPD-MA is as follows: In the case of PDT, the amount of photosensitizer bound to or taken up into the target cells during the time interval between injection of the agent and laser irradiation is critica...Continue Reading

Citations

Nov 8, 2011·Lasers in Surgery and Medicine·Cheng S Jin, Gang Zheng
Aug 8, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Lin Zhu, Vladimir P Torchilin
Apr 28, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Woo-Dong JangIn-Hwan Hwang
Jan 21, 2015·Chemical Reviews·Sasidharan Swarnalatha LuckyYong Zhang

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