Antiapoptosis effect of ZiShen prescription to increase learning and memory abilities of compound Alzheimer's disease model rats

Journal of Cellular Biochemistry
Zhiqiang WeiXin Li

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease characterized progressive memory loss and cognitive impairment. In previous studies, the activities of extracts of Chinese medicinal herbs to treat brain function disorders caused by AD have already been reported. ZiShen prescription was a traditional Chinese medicine (TCM) compound prescription reformed for AD disease based on the basic theory of TCM. To explore the effect of ZiShen (kidney-reinforcing) prescription on the learning and memory abilities, we made compound AD model rats by injecting d-galactose and ibotenic acid into the abdominal cavity to damage both sides of the nucleus basalis of Meynert with ibotenic acid. The trisected Y-maze was used to test the learning and memory abilities of AD model rats before and after treatment by ZiShen prescription and Piracetam. To investigate the mechanism of ZiShen prescription, the expressions of apoptosis-related genes (Bcl-2/Bax) in the cortex and hippocampus of compound AD model rats were detected in the cortex and hippocampus. The results show that, comparing with Piracetam, a clinical medicine to promote the thinking and memory for AD patients, ZiShen prescription significantly increased the learning and memory abili...Continue Reading

References

Jan 1, 1995·Acta Neuropathologica·H LassmannH M Wisniewski
Jan 22, 2004·JAMA : the Journal of the American Medical Association·Pierre N TariotUNKNOWN Memantine Study Group
Oct 25, 2008·Health Policy·Judy Xu, Yue Yang
Feb 11, 2009·The Journal of Allergy and Clinical Immunology·Xiu-Min Li, Laverne Brown
Jul 31, 2009·The New England Journal of Medicine·Arjen M DondorpNicholas J White
Jan 20, 2010·Lancet Neurology·Clifford R JackJohn Q Trojanowski
Jul 28, 2011·Taiwanese Journal of Obstetrics & Gynecology·Tzong-Yuan WuTzyy-Rong Jinn
Jun 8, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Qi ShiWei Wang
Nov 2, 2013·Current Neuropharmacology·Mirjana B ColovićVesna M Vasić
Jan 9, 2014·Biochemical Pharmacology·Christiane Reitz, Richard Mayeux
Feb 26, 2015·Pharmacological Reports : PR·Anil Kumar Ekavali
May 20, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·UNKNOWN Alzheimer’s Association
May 27, 2015·Nature Neuroscience·Karl Herrup
Aug 16, 2017·International Review of Neurobiology·Melanie-Jayne R HowesPeter J Houghton
Sep 20, 2017·The American Journal of Chinese Medicine·Simin ZhouHong Xiao

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