Antiapoptotic and immunomodulatory effects of chlorophyllin

Molecular Immunology
Deepak SharmaK B Sainis

Abstract

Chlorophyllin (CHL) was earlier shown to reduce the level of intracellular ROS and apoptosis induced by ionizing radiation and 2,2'-azobis(2-propionimidinedihydrochloride) (AAPH). In the present studies, the effect of CHL on radiation-induced immunosuppression and modulation of immune responses in mice was examined. Chlorophyllin inhibited the in vitro lymphocyte proliferation induced by concanavalin A (Con A) in a dose dependent manner at doses>or=50 microM. At lower doses (10 microM) CHL significantly inhibited activation induced cell death (AICD) in Con A stimulated spleen cells. Spleen cells obtained from CHL treated mice showed an inhibition of response to Con A depending on dose of CHL and the time after its administration. Spleen cells obtained from CHL treated mice (24 h) showed lower inhibition of response to Con A following in vitro (5 Gy) as well as whole body irradiation (2 Gy). The expression of antiapoptotic genes bcl-2 and bcl-xL was up-regulated in these cells. Chlorophyllin treatment of mice led to splenomegaly and increase in the number of peritoneal exudate cells (PEC). The numbers of T cells, B cells and macrophages in the spleen were also increased. Increased phagocytic activity was seen in PEC obtained fro...Continue Reading

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Citations

Jul 3, 2009·Biological & Pharmaceutical Bulletin·Ayano ItohKiyohito Yagi
Apr 21, 2009·International Immunopharmacology·Rahul CheckerT B Poduval
Nov 21, 2015·International Immunopharmacology·Wei LeiKevin L Fritsche
Jun 13, 2015·Applied Microbiology and Biotechnology·Viola StrompfováAndrea Lauková
Nov 24, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Laura CariddiLiliana Sabini
Apr 22, 2016·Toxicology Mechanisms and Methods·Gláucia Fernanda Rocha D EpiroMário Sérgio Mantovani
Jun 7, 2007·Journal of Cellular Biochemistry·Himanshi Narang, Malini Krishna
Jul 3, 2021·Macromolecular Bioscience·Carlotta PucciGianni Ciofani

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