Antiapoptotic potential of herbal drugs in cardiovascular disorders: an overview

Pharmaceutical Biology
Rahila AhmadUma Bhandari

Abstract

Cardiomyocyte apoptosis has been reported in a number of cardiovascular disorders, including myocardial infarction, ischemia-reperfusion, end-stage heart failure, arrhythmogenic right ventricular dysplasia, and adriamycin-induced cardiomyopathy. Prevention of myocyte apoptosis has emerged as a potential new target in a multimodel therapeutic approach to cardiac disease. Herbal therapy may be an alternative strategy for the prevention and treatment of heart disease. The present review summarizes the list of plants/herbal formulations studied for their antiapoptotic activity in cardiovascular disorders. However, despite extensive positive research data from experimental studies for herbal drugs in cardiovascular disorders, and the anecdotal clinical experience of many practitioners and patients, its potential in the field of cardiac apoptosis remains largely untapped, and large scale clinical trials are needed to explore the potential of herbal medicines as a new treatment regime for targeting cardiovascular apoptosis.

References

Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Jul 1, 1987·Progress in Cardiovascular Diseases·L C Becker, G Ambrosio
Sep 1, 1981·American Heart Journal·R E RudeE Braunwald
Jan 1, 1995·Cancer Chemotherapy and Pharmacology·B C HüskenA Bast
Oct 22, 1993·Cell·D M HockenberyS J Korsmeyer
Oct 1, 1994·The Journal of Clinical Investigation·R A GottliebR L Engler
Jan 1, 1994·Immunology Today·T M Buttke, P A Sandstrom
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·C ThiemermannJ R Vane
Apr 17, 1997·The New England Journal of Medicine·G OlivettiP Anversa
Aug 1, 1997·Circulation Research·W R MacLellan, M D Schneider
Jan 1, 1997·British Medical Bulletin·A H Wyllie
Jun 20, 1998·Circulation Research·A Haunstetter, S Izumo
Jul 1, 1998·British Journal of Pharmacology·N Venkatesan
Feb 17, 1999·Genes & Development·Q L Deveraux, J C Reed
Aug 17, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M C Willingham
Feb 19, 2000·Cancer Letters·L Davis, G Kuttan
Mar 18, 2000·Journal of Ethnopharmacology·J N Dhuley
Mar 21, 2000·Molecular and Cellular Biochemistry·D D KittsC Hu
Jun 13, 2000·Circulation Research·P M Kang, S Izumo
Jul 25, 2000·Journal of Ethnopharmacology·P Scartezzini, E Speroni
Aug 30, 2000·Cardiovascular Research·N S DhallaN Makino
May 23, 2001·Archives of Biochemistry and Biophysics·P S TappiaN S Dhalla
Jun 30, 2001·European Journal of Pharmacology·Y M LeeM H Yen
Nov 22, 2001·Molecular and Cellular Biochemistry·M SharmaD S Arya
Jul 2, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marcus S CookeJoseph Lunec
Aug 23, 2003·Circulation Research·James N WeissPeipei Ping
Sep 12, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M H Abdel-WahabF M A Hamada
Oct 2, 2003·Biological & Pharmaceutical Bulletin·Raghavan GovindarajanPalpu Pushpangadan
Dec 4, 2003·The Journal of Laboratory and Clinical Medicine·Dinender Kumar, Bodh I Jugdutt
Apr 14, 2004·Basic & Clinical Pharmacology & Toxicology·Ipseeta MohantySuresh Kumar Gupta

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Citations

Apr 25, 2013·International Journal of Biological Macromolecules·Jing ZhangQiangsun Zheng
Apr 12, 2014·The Journal of Pharmacy and Pharmacology·Yan-Ru LiuGuo-Bin Zhang
Jun 13, 2014·Phytotherapy Research : PTR·Effat BehravanHossein Hosseinzadeh

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