Antiarrhythmic actions of meptazinol, a partial agonist at opiate receptors, in acute myocardial ischaemia

British Journal of Pharmacology
O FagbemiL Szekeres

Abstract

1 The intravenous administration, to anaesthetized rats, of meptazinol (1 and 2 mg kg-1), a partial agonist at opiate receptors, greatly reduced the incidence of ventricular extrasystoles that resulted from acute coronary artery occlusion. The incidence of ventricular fibrillation (VF) was reduced from 50% (in the controls) to 10% and the mortality from 30% to zero. 2 In similar doses, pretreatment with meptazinol also reduced ventricular arrhythmias, including fibrillation, in conscious rats subjected to coronary artery occlusion. In this model, survival at 16 h was increased from 27% in the controls to 50% and 83% respectively in rats pretreated with 1 and 2 mg kg-1 of the drug. 3 In antiarrhythmic doses, meptazinol had little effect on either heart rate or systemic arterial blood pressure. 4 Intracellular action potential recordings from papillary muscle removed from rats given meptazinol (2 mg kg-1) 15 min previously showed an increase in APD50 and APD90 of more than 40%. There was no effect on dV/dtmax. When superfused with meptazinol in vitro normal rat papillary muscle stimulated at 1 or 3 Hz showed an increase in APD90 and a decrease in dV/dtmax. 5 The antiarrhythmic effect of meptazinol in these models can probably be ...Continue Reading

References

Jun 1, 1979·British Journal of Anaesthesia·C JordanJ G Jones
Jan 1, 1979·General Pharmacology·S Rashid, J F Waterfall
Aug 1, 1970·British Journal of Pharmacology·B N Singh, E M Vaughan Williams
Aug 1, 1982·British Journal of Pharmacology·O FagbemiL Szekeres

Citations

Oct 14, 1986·European Journal of Pharmacology·S W Rabkin, O Roob
Nov 1, 1995·Clinical and Experimental Pharmacology & Physiology·Leonid N Maslov, Y B Lishmanov
Mar 1, 1990·Pharmacology & Toxicology·K G Helgesen, H Refsum
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Feb 21, 2014·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Leonid N MaslovJian-Ming Pei
Sep 20, 2018·Non-coding RNA·Zesergio MeloRaquel Echavarria
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Related Concepts

Nerve Impulses
Anesthesia Procedures
Metazoa
Cardiac Depressants
Cardiac Arrhythmia
Azepines
Coronary Heart Disease
Meptid
August Rats
Opioid Receptor

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