Antiarrhythmic actions of verapamil against ischaemic arrhythmias in the rat

British Journal of Pharmacology
M J CurtisM J Walker

Abstract

The actions of intravenous verapamil against arrhythmias induced by occlusion of a coronary artery were investigated in conscious rats. Verapamil (2-20 mg kg-1, i.v. given pre-occlusion) dose-dependently reduced arrhythmias in rats with either large or small occluded zones at an ED50 of 6 mg kg-1. This dose was effective when given immediately post-occlusion. Severe arrhythmias, as opposed to PVC, were preferentially reduced. In conscious, and pentobarbitone-anaesthetized rats, verapamil (6 mg kg-1) had different effects on electrically-induced arrhythmias, and the ECG, from an equi-effective anti-arrhythmic dose of quinidine (20 mg kg-1, i.v.). Quinidine decreased following frequency, but increased threshold current and pulse width, whereas verapamil did not. Both drugs increased P-R interval, but only quinidine increased QRS and Q-T intervals. Thirty minutes post-occlusion, the verapamil content of tissue and blood was determined after a 6 mg kg-1 dose given pre- or post-occlusion. Measurable levels of verapamil were found in both normal and ischaemic myocardium. Plasma and plasma water concentrations were 3.6 +/- 0.8 mumol l-1 and 0.6 +/- 0.1 mumol l-1 (mean +/- s.e. mean), respectively following post-occlusion administratio...Continue Reading

References

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Citations

May 1, 1989·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·B A MacLeodM J Walker
Nov 15, 1988·European Journal of Pharmacology·R ReichhalterW Kobinger
Jan 21, 1992·European Journal of Pharmacology·L N IgwemezieM J Walker
Aug 14, 1992·European Journal of Pharmacology·P G HowardM J Walker
Dec 1, 1989·Journal of Molecular and Cellular Cardiology·G AksnesA Ilebekk
Jan 1, 1985·Molecular Aspects of Medicine·J H BottingM J Walker
Aug 1, 1993·Journal of Pharmacological and Toxicological Methods·P H CheungM J Walker
Feb 10, 2000·European Journal of Pharmacology·H NaitoK Hashimoto
Dec 1, 1989·British Journal of Pharmacology·B A MacLeodM J Walker
Aug 28, 2003·Clinical and Experimental Hypertension : CHE·D W RodenbaughS E DiCarlo
Jan 30, 2013·Journal of Pharmacological and Toxicological Methods·A Shea Hatcher, Hugh Clements-Jewery
Jan 22, 2009·British Journal of Pharmacology·Hugh Clements-JeweryMichael J Curtis
Jan 13, 2006·British Journal of Pharmacology·M J A Walker
Oct 7, 2014·Clinical and Experimental Pharmacology & Physiology·James R BellLea Md Delbridge
Dec 1, 1986·British Journal of Pharmacology·R BrageC Rodriguez
Jan 27, 2009·Current Opinion in Pharmacology·Hugh Clements-JeweryMichael J Curtis
May 17, 2014·Frontiers in Pharmacology·James R BellLea M D Delbridge
Apr 7, 2017·Journal of Cardiovascular Pharmacology and Therapeutics·Laura A HundahlThomas Jespersen
May 1, 1987·Biopharmaceutics & Drug Disposition·E L Todd, D R Abernethy

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