Antiarrhythmic drug-induced smell and taste disturbances: A case report and literature review

Medicine
Xiaoru CheHuan Wang

Abstract

Metoprolol and amiodarone are common antiarrhythmic drugs used in clinics throughout the world. The taste and smell alterations induced by antiarrhythmic drugs remain uncommon throughout the world, with less than 10 reported cases. In this case report, we describe a case of a 73-year-old female, diagnosed with arrhythmias, was treated for metoprolol. At the third week of metoprolol treatment, the patient noticed a qualitative change in her ability to smell, also called dysosmia. After the metoprolol was tapered, her ability to smell was recovered. However, her arrhythmia was getting worse and the patient was given amiodarone. After using amiodarone for about 2 weeks, the patient felt hypogeusia, or loss of taste sensation. The patient was diagnosed as dysosmia and taste disturbance induced by the antiarrhythmic drugs. After noticed the side effects of the antiarrhythmic drugs, we asked the patient to abandon the drugs and have a radiofrequency ablation. Her ability of smell and taste were recovered after withdrawing the antiarrhythmic drugs. Also, in the follow-up appointment, she reported no complaints of smell or taste anymore. These rare sensory disorders induced by anti-arrhythmic drugs were less documented in past literatu...Continue Reading

References

Sep 8, 1979·Lancet·P H Vlasses, R K Ferguson
Jan 1, 1975·Acta Pharmacologica Et Toxicologica·N O BodinI Skänberg
Apr 15, 1988·Biological Psychiatry·M D WarnerP A Berger
Jan 1, 1985·Annals of Internal Medicine·J L Levenson, K Kennedy
May 1, 1985·Annals of Internal Medicine·J L Berman
Nov 1, 1994·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·R I Henkin
Feb 17, 1996·Lancet·R G SchliengerW E Haefeli
Jul 4, 1998·Annals of Internal Medicine·M Heeringa, E P van Puijenbroek
May 3, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·N Ohkoshi, S Shoji
Nov 30, 2002·BMJ : British Medical Journal·Xavier CastellsJoan-Ramon Laporte
May 30, 2006·Auris, Nasus, Larynx·Tadashi Ishimaru, Hideaki Yokogawa
Feb 6, 2007·British Journal of Clinical Pharmacology·Balakrishnan Sadasivam, Ratinder Jhaj
Nov 3, 2007·The American Journal of Medicine·Toru MaruyamaMine Harada
Aug 20, 2009·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Erin R Briggs
Sep 2, 2011·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Marco TuccoriCorrado Blandizzi
Jul 10, 2013·Heart & Lung : the Journal of Critical Care·Theodore E Van CottJanet R Thorlton

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