Antiarrhythmic effect linked to melatonin cardiorenal protection involves AT1 reduction and Hsp70-VDR increase

Journal of Pineal Research
Natalia Jorgelina PradoWalter Manucha

Abstract

Lethal ventricular arrhythmias increase in patients with chronic kidney disease that suffer an acute coronary event. Chronic kidney disease induces myocardial remodeling, oxidative stress, and arrhythmogenesis. A manifestation of the relationship between kidney and heart is the concomitant reduction in vitamin D receptor (VDR) and the increase in angiotensin II receptor type 1 (AT1 ). Melatonin has renal and cardiac protective actions. One potential mechanism is the increase in the heat shock protein 70 (Hsp70)-an antioxidant factor. We aim to determine the mechanisms involved in melatonin (Mel) prevention of kidney damage and arrhythmogenic heart remodeling. Unilateral ureteral-obstruction (UUO) and sham-operated rats were treated with either melatonin (4 mg/kg/day) or vehicle for 15 days. Hearts and kidneys from obstructed rats showed a reduction in VDR and Hsp70. Associated with AT1 up-regulation in the kidneys and the heart of UUO rats also increased oxidative stress, fibrosis, apoptosis, mitochondrial edema, and dilated crests. Melatonin prevented these changes and ventricular fibrillation during reperfusion. The action potential lengthened and hyperpolarized in melatonin-treated rats throughout the experiment. We conclude...Continue Reading

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Citations

Oct 22, 2019·Journal of Pineal Research·Nan FangLifeng Liu
Jan 12, 2020·Current Hypertension Reports·Isabel QuesadaClaudia Castro
Aug 4, 2020·Bulletin of Experimental Biology and Medicine·O G BernikovaJ E Azarov
Mar 12, 2020·International Journal of Molecular Sciences·Natalia Jorgelina PradoEmiliano Raúl Diez
Sep 24, 2020·Cell Death Discovery·Xinyu LiQuan Zhuang
Feb 1, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Mohsen ImenshahidiHossein Hosseinzadeh
Sep 22, 2020·Pharmacology & Therapeutics·Jason D Vadhan, Robert C Speth
Mar 6, 2021·The American Journal of the Medical Sciences·Jie SongWei Zhu
Apr 2, 2021·Oxidative Medicine and Cellular Longevity·Margarita Segovia-RoldanEsther Pueyo
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmet Ozer SehirliNedime Serakinci

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