Antiarrhythmic effects of the thromboxane antagonist BM 13.177

European Journal of Pharmacology
C L Wainwright, J R Parratt

Abstract

The effects of the thromboxane antagonist BM 13.177 (5 mg kg-1 + 0.15 mg kg-1 min-1) was investigated on the ventricular arrhythmias that result from coronary artery occlusion and reperfusion in anaesthetised open-chest greyhounds. BM 13.177 markedly reduced the severity and incidence of arrhythmias resulting from ischaemia; the number of ventricular ectopic beats was reduced from 1,084 +/- 159 (in controls) to 544 +/- 179 (in dogs given BM 13.177) and the incidences of ventricular tachycardia (VT) and ventricular fibrillation (VF) were reduced from 86 to 22% and from 30 to 10% respectively. Following reperfusion the incidence of VF was 86% in controls and 44% in dogs given BM 13.177. Thus the total incidence of VF during the combined ischaemia-reperfusion insult was significantly reduced by treatment with BM 13.177 from 90% (in control dogs) to 50%. These results lend further support to the hypothesis that thromboxane is involved in the genesis of arrhythmias and that blockade of thromboxane receptors may be a suitable approach to antiarrhythmic therapy under conditions of ischaemia and reperfusion.

References

May 17, 1979·The New England Journal of Medicine·S Moncada, J R Vane
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Oct 1, 1987·Journal of Molecular and Cellular Cardiology·J R ParrattC L Wainwright

Citations

May 1, 1988·Cardiovascular Drugs and Therapy·J R Parratt
Aug 10, 1990·European Journal of Pharmacology·N NakahataH Nakanishi
Feb 1, 1988·European Journal of Clinical Investigation·K Jaschonek, C P Muller
Feb 1, 1993·American Heart Journal·T G SaldeenJ L Mehta
Sep 1, 1991·Medicinal Research Reviews·S E Hall

Related Concepts

SK&F 95587
Metazoa
Cardiac Depressants
Cardiac Arrhythmia
Carbon Dioxide
Coronary Heart Disease
Canis familiaris
Hemodynamics
Dioxygen
Sulfonamides

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.