PMID: 6414246Aug 1, 1983Paper

Antiarrhythmic effects of tocainide and lidocaine in dogs

Acta Pharmacologica Et Toxicologica
G AbergR Moller

Abstract

To compare the antiarrhythmic activities of tocainide and lidocaine in dogs, a protocol was designed where the drug plasma levels were increased stepwise. This was achieved by computerizing bolus doses and infusion rates, using pharmacokinetic equations with constants, derived from previous experiments in similar animals. In conscious coronary-ligated dogs with ischaemic arrhythmias both compounds were active, causing a 50% reduction in VPB's at plasma concentrations of 5.0 micrograms/ml (tocainide) and 3.5 micrograms/ml (lidocaine). "Clearing" of catecholamine-induced arrhythmias was not obtained in any of six dogs given tocainide and only in two out of six dogs given lidocaine.

References

May 1, 1979·Journal of Cardiovascular Pharmacology·Y Trolèse-MonghealP Duchêne-Marullaz
Oct 1, 1968·European Journal of Pharmacology·E Krüger-Thiemer

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Citations

Jan 1, 1986·Drug Intelligence & Clinical Pharmacy·E ForrenceC Mullen

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