PMID: 108025Feb 5, 1979

Antiarrhythmic properties of 3-(2-hydroxy-3 isopropylamino-propoxy)-3 phenyl-2 isoindolinone-1, (RS, SR) in the dog

Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles
J Y DetailleL Julou

Abstract

In the Dog, 3-(2-hydroxy-3 isopropylamino-proxy)-2-phenyl-1-isoindolinone (RS, SR) possesses an anti-arrhythmic activity similar to that of quinidine but at dose levels 2 to 6 times lower than in the case of the latter compound. Furthermore, in contrast to quinidine, at the dose levels where the antiarrhythmic activity is well observed, the compound is devoid of hypotensive activity and of depressive action on cardiac contractility. The first clinical studies of this compound have shown its usefulness in the treatment of ventricular and supraventricular arrhythmias.

Related Concepts

Cardiac Depressants
Diastolic Blood Pressure
Canis familiaris
Dose-Response Relationship, Drug
Indoles
Myocardial Contraction
Ouabain
Propanolamines
Quinidex
Tachycardia

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