Antiarrhythmics cure brain arrhythmia: The imperativeness of subthalamic ERG K+ channels in parkinsonian discharges

Science Advances
Chen-Syuan HuangYa-Chin Yang

Abstract

ERG K+ channels have long been known to play a crucial role in shaping cardiac action potentials and, thus, appropriate heart rhythms. The functional role of ERG channels in the central nervous system, however, remains elusive. We demonstrated that ERG channels exist in subthalamic neurons and have similar gating characteristics to those in the heart. ERG channels contribute crucially not only to the setting of membrane potential and, consequently, the firing modes, but also to the configuration of burst discharges and, consequently, the firing frequency and automaticity of the subthalamic neurons. Moreover, modulation of subthalamic discharges via ERG channels effectively modulates locomotor behaviors. ERG channel inhibitors ameliorate parkinsonian symptoms, whereas enhancers render normal animals hypokinetic. Thus, ERG K+ channels could be vital to the regulation of both cardiac and neuronal rhythms and may constitute an important pathophysiological basis and pharmacotherapeutic target for the growing list of neurological disorders related to "brain arrhythmias."

References

Jun 1, 1991·Lancet·Y Agid
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·J W Warmke, B Ganetzky
Jan 1, 1997·Annual Review of Neuroscience·D A McCormick, T Bal
Jun 1, 1997·The Journal of Physiology·N ChiesaE Wanke
Mar 5, 1998·Circulation Research·E FickerA M Brown
May 14, 1998·Neuroscience and Biobehavioral Reviews·J J Eggermont
Oct 15, 1998·The New England Journal of Medicine·P LimousinA L Benabid
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·J S MitchesonM C Sanguinetti
Feb 22, 2001·Annual Review of Physiology·D A McCormick, D Contreras
Mar 22, 2002·Pflügers Archiv : European journal of physiology·Manjula WeerapuraStanley Nattel
Sep 11, 2002·Trends in Neurosciences·Mark D BevanCharles J Wilson
Dec 31, 2002·Physiological Reviews·Edward Perez-Reyes
May 17, 2003·Journal of Neurophysiology·Tiziana SaccoFilippo Tempia
Dec 25, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Robert B ClarkWayne R Giles
Sep 24, 2004·The European Journal of Neuroscience·Stephanie J CraggMark D Bevan
Feb 14, 2006·Molecular Pharmacology·Kaichiro KamiyaMichael C Sanguinetti
Mar 24, 2006·Nature·Michael C Sanguinetti, Martin Tristani-Firouzi
Jan 11, 2007·Archives of Neurology·Mahlon R DeLong, Thomas Wichmann
Jan 26, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Francesco FurlanLaura Ballerini
Jun 5, 2007·Trends in Neurosciences·John R Huguenard, David A McCormick
Jun 27, 2007·British Journal of Pharmacology·D StorkS Hering
Oct 2, 2007·Schizophrenia Bulletin·Paul D ShepardEdwin S Levitan

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy
MDS

Software Mentioned

SigmaPlot
Statistical Package for the Social Sciences
Excel
GraphPad
EthoVision
Prism
pCLAMP

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.