Antiatherogenic Effect of Resveratrol Attributed to Decreased Expression of ICAM-1 (Intercellular Adhesion Molecule-1)

Arteriosclerosis, Thrombosis, and Vascular Biology
Youngsik SeoHeonyong Park

Abstract

Objective- Increasing evidence shows that resveratrol has antiatherogenic effects, but its underlying mechanisms are unknown. Thus, we evaluated the molecular mechanisms underlying the antiatherogenic effect of resveratrol. Approach and Results- Using the previously established mouse atherosclerosis model of partial ligation of the left carotid artery, we evaluated the role of resveratrol in antiatherosclerosis. We attempted to determine the mechanisms associated with focal adhesions using vascular endothelial cells. The results showed that resveratrol stimulated focal adhesion kinase cleavage via resveratrol-increased expression of lactoferrin in endothelial cells. Furthermore, we found that an N-terminal focal adhesion kinase fragment cleaved by resveratrol contained the FERM (band 4.1, ezrin, radixin, and moesin)-kinase domain. Furthermore, resveratrol inhibited lipopolysaccharide-stimulated adhesion of THP-1 human monocytes by decreased expression of ICAM-1 (intercellular adhesion molecule-1). A decreased ICAM-1 level was also observed in the left carotid artery of mice treated with resveratrol. To understand the relationship between resveratrol-induced antiinflammation and focal adhesion disruption, endothelial cells were ...Continue Reading

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Citations

Jan 23, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Garrett FairmanMireille Ouimet
Mar 4, 2020·International Journal of Molecular Sciences·Gabriel Leonardo MagrinReinhard Gruber
Aug 6, 2020·Experimental Biology and Medicine·Junyao Wang, Shiyanjin Zhang
Aug 25, 2020·Oxidative Medicine and Cellular Longevity·Liangkai ChengCaiyan Wang
Aug 13, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sujeong JangHeonyong Park
Jan 26, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shahram AgahJavad Heshmati
Jan 8, 2021·Plants·Alessio VallettaFrancesca Leonelli

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