Antiatherogenic effects of ellagic acid and urolithins in vitro

Archives of Biochemistry and Biophysics
Laura MeleDaniele Del Rio

Abstract

Atherosclerosis, one of the leading causes of death worldwide, is characterized by impaired endothelial function and lipid metabolism, among other factors. Ellagitannins are a class of phenolic compounds that may play a role in cardiovascular health. This work aimed to study the potential atheroprotective effects of urolithins, ellagitannin-derived gut microbiota metabolites, on different key factors in atherosclerosis development: the ability of monocytes to adhere to endothelial cells and the uptake and efflux of cholesterol by macrophages. The biotransformations urolithins undergo in peripheral cells were also evaluated. Results indicated that some urolithins and ellagic acid were able to reduce the adhesion of THP-1 monocytes to human umbilical vein endothelial cells (HUVECs) and the secretion of a cellular adhesion molecule (sVCAM-1) and pro-inflammatory cytokine (IL-6). Urolithin C, a combination of urolithins A and B, and ellagic acid also decreased the accumulation of cholesterol in THP-1-derived macrophages, but they were not able to promote cholesterol efflux. The analysis of cell media by UHPLC-ESI-MS(n) indicated urolithins and ellagic underwent extensive metabolism, with sulfate and methyl conjugation. This evidenc...Continue Reading

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Citations

Mar 22, 2016·Archives of Biochemistry and Biophysics·Christine Morand, Helmut Sies
Aug 5, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Valentina SpigoniDaniele Del Rio
Mar 2, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Monia SaviDaniele Del Rio
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