Antibacterial 3D bone scaffolds for tissue engineering application

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Jitendra PantHitesh Handa

Abstract

Open bone fractures are not only difficult to heal but also are at a high risk of infections. Annual cases of fractures which result from osteoporosis amount to approximately 9 million. Endogenously released nitric oxide (NO) has been shown to play a role in osteogenic differentiation in addition to eradicating infection against a wide variety of pathogens. In the current work, antimicrobial NO releasing 3D bone scaffolds were fabricated using S-nitroso-N-acetyl-penicillamine (SNAP) as the NO donor. During fabrication, nano-hydroxyapatite (nHA) was added to each of the scaffolds in the concentration range of 10-50 wt % in nHA-starch-alginate and nHA-starch-chitosan scaffolds. The mechanical strength of the scaffolds increased proportionally to the concentration of nHA and 50 wt % nHA-starch-alginate possessed the highest load bearing capacity of 203.95 ± 0.3 N. The NO flux of the 50 wt % nHA-starch-alginate scaffolds was found to be 0.50 ± 0.06 × 10-10 mol/min/mg initially which reduced to 0.23 ± 0.02 × 10-10 over a 24 h period under physiological conditions. As a result, a 99.76% ± 0.33% reduction in a gram-positive bacterium, Staphylococcus aureus and a 99.80% ± 0.62% reduction in the adhered viable colonies of gram-negative ...Continue Reading

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Citations

Jun 6, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Monika BudnickaAgnieszka Gadomska-Gajadhur
Jul 22, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Katharina SchuhladenAldo R Boccaccini
Feb 5, 2021·Frontiers in Bioengineering and Biotechnology·Albert Thomas AnastasioJoseph S Fernandez-Moure
Aug 12, 2019·ACS Biomaterials Science & Engineering·Jitendra PantHitesh Handa
Oct 30, 2021·ACS Applied Materials & Interfaces·Yun QianElizabeth J Brisbois

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