Antibacterial action of amphipathic derivatives of isoniazid against the Mycobacterium avium complex

Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology
N RastogiH L David

Abstract

The antibacterial action of amphipathic derivatives of isoniazid (INH) as compared to the parent hydrophilic molecule was determined against the bacteria of the Mycobacterium avium complex (MAC) using a 7H11 agar-dilution method. The results obtained showed a higher activity of 1-isonicotinyl-2-palmitoyl hydrazine and 1-isonicotinyl-2-(12 hydroxy dodecanoyl) hydrazine as compared to INH. However, when one mannose residue was terminally attached to the fatty acid chain of the latter, it lost its anti-MAC activity. 1-isonicotinyl-2-D-galacturonic acid hydrazone (but not hydrazine) also showed increased activity against MAC. Although pristinamycin was shown to bind to M. avium surface lipids, the INH-pristinamycin derivative was not more active than INH alone. These findings are discussed in respect to a proposed mechanism of diffusion across a lipid barrier.

References

Apr 1, 1987·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·H L DavidM F Thorel

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Citations

May 1, 1991·Research in Microbiology·H Nikaido, V Jarlier
Jan 1, 1996·Research in Microbiology·N Rastogi, J O Falkinham
Feb 5, 1998·Letters in Applied Microbiology·P IbrahimM R Barer
May 1, 1990·Antimicrobial Agents and Chemotherapy·N RastogiH L David
Aug 1, 1991·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·N RastogiH L David
Feb 8, 2000·The Journal of Antimicrobial Chemotherapy·L J PiddockV Ricci

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Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology
H L DavidM F Thorel
Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology
N RastogiH L David
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