Antibacterial activities of a new brominated diterpene from Borneon Laurencia spp.

Marine Drugs
Charles Santhanaraju VairappanZhan Zhaoqi

Abstract

In our continuous interest to study the diversity of halogenated metabolites of Malaysian species of the red algal genus Laurencia, we examined the chemical composition of five populations of unrecorded Laurencia sp. A new brominated diterpene, 10-acetoxyangasiol (1), and four other known metabolites, aplysidiol (2), cupalaurenol (3), 1-methyl-2,3,5-tribromoindole (4), and chamigrane epoxide (5), were isolated and identified. Isolated metabolites exhibited potent antibacterial activities against clinical bacteria, Staphylococcus aureus, Staphylococcus sp., Streptococcus pyogenes, Salmonella sp. and Vibrio cholerae.

References

Aug 23, 2008·Phytochemistry·Charles Santhanaraju VairappanMichio Masuda

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Citations

Sep 21, 2013·Biofouling·Sophie MieszkinJames A Callow
Feb 13, 2015·Marine Drugs·Louisi Souza de OliveiraFabiano L Thompson
Jun 20, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R ChatterN Vergnolle
Mar 2, 2013·Chemical Reviews·Bin-Gui WangJian-Chun Zhao
Nov 4, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katarzyna WińskaMirosław Anioł
Feb 23, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Takashi Kamada, Charles Santhanaraju Vairappan
Dec 24, 2011·Natural Product Reports·John W BluntMichèle R Prinsep

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Methods Mentioned

BETA
column chromatography
Si
gel column chromatography

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