Abstract
Temocillin, a 6-alpha-methoxy penicillin, inhibited 90% of strains of Escherichia coli, Klebsiella pneumoniae, Citrobacter, Proteus, Providencia, Salmonella, and Shigella at a concentration of less than or equal to 16 micrograms/ml. Haemophilus influenzae and Neisseria gonorrhoea were inhibited by less than or equal to 1 microgram/ml. Changing the medium or pH of the cultures did not alter the minimal inhibitory concentrations, which were similar in broth and human serum, as were the minimal bactericidal concentrations. An increase in inoculum size from 10(5) to 10(7) colony-forming units increased concentration required for inhibition. Temocillin inhibited strains resistant to ampicillin, ticarcillin, cefazolin, cefamandole, and cefoxitin. Most Pseudomonas aeruginosa strains and other Pseudomonas spp. and Acinetobacter spp. were resistant, as were gram-positive organisms. Temocillin was not hydrolyzed by the common plasmid and chromosomal beta-lactamases but inhibited them. The resistance of certain gram-negative bacilli to temocillin seemed to be a result of failure of the molecule to enter through the cell wall, since combination of temocillin with EDTA made Pseudomonas, Acinetobacter, and Enterobacter strains susceptible to...Continue Reading
References
Mar 1, 1975·The Journal of Clinical Investigation·J F AcarP A Ruch
Jun 1, 1979·Antimicrobial Agents and Chemotherapy·C C Sanders, W E Sanders
Sep 1, 1979·The Journal of Antibiotics·K P Fu, H C Neu
Jul 1, 1979·The Journal of Antimicrobial Chemotherapy·M Matthew
Apr 1, 1979·Antimicrobial Agents and Chemotherapy·P M Waterworth, A M Emmerson
May 1, 1978·Antimicrobial Agents and Chemotherapy·H C Neu, K P Fu
Jun 1, 1976·The Journal of Antimicrobial Chemotherapy·R B Sykes, M Matthew
Apr 1, 1972·Antimicrobial Agents and Chemotherapy·C H O'CallaghanA H Shingler
Feb 23, 1972·Journal of the American Chemical Society·L D CamaB G Christensen
May 16, 1980·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T Yoshida
Nov 1, 1980·Antimicrobial Agents and Chemotherapy·N H Georgopapadakou, F Y Liu
Oct 1, 1981·The Journal of Antibiotics·T A HoffmanD H Bercuson
Jul 1, 1981·Antimicrobial Agents and Chemotherapy·B SlocombeR Sutherland
Citations
Feb 1, 1985·European Journal of Clinical Microbiology·P C FuchsR N Jones
Jan 1, 1984·Diagnostic Microbiology and Infectious Disease·P C FuchsC Thornsberry
Aug 2, 2012·Organic & Biomolecular Chemistry·Ryan B Pelto, R F Pratt
Jan 1, 1986·Journal of Ocular Pharmacology·I H Leopold
Dec 20, 2008·The Journal of Antimicrobial Chemotherapy·David M Livermore, Paul M Tulkens
Jan 1, 1984·Antimicrobial Agents and Chemotherapy·L Verbist, J Verhaegen
May 1, 1986·Antimicrobial Agents and Chemotherapy·W Mandell, H C Neu
May 19, 1990·BMJ : British Medical Journal·R Finch
Jan 7, 2014·Journal of Pharmaceutical and Biomedical Analysis·Ana C Miranda BastosFrançoise Van Bambeke
Jan 1, 1986·Scandinavian Journal of Infectious Diseases·H GorisD van der Waaij
Oct 1, 1993·European Journal of Biochemistry·A MatagneJ M Frère
Jan 10, 2016·The Journal of Antimicrobial Chemotherapy·K GhathianN Frimodt-Møller
Nov 26, 2009·Bioorganic & Medicinal Chemistry·S A AdediranR F Pratt
Jul 19, 2011·Critical Care Research and Practice·Rishi H-P Dhillon, John Clark
Jun 30, 2006·Bioorganic & Medicinal Chemistry·S A AdediranR F Pratt
Feb 26, 2015·Clinical Biochemistry·Perrin Ngougni PokemArnaud Capron
Aug 19, 2008·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Lisa KentJ Stuart Elborn
Oct 19, 2014·The Journal of Antimicrobial Chemotherapy·Stewart BarkerThomas J Smith
Jan 1, 1983·Infection·H C Neu
Feb 6, 2019·Antimicrobial Agents and Chemotherapy·Elise T ZeiserKrisztina M Papp-Wallace
Nov 7, 2019·Antimicrobial Agents and Chemotherapy·Michael D SaccoYu Chen
Aug 8, 2018·The Journal of Antimicrobial Chemotherapy·M BerleurV de Lastours
Aug 30, 2017·Clinical Pharmacokinetics·Kevin Alexandre, Bruno Fantin
Apr 5, 2021·Diagnostic Microbiology and Infectious Disease·Eric FarfourUNKNOWN GMC study group
Jul 6, 2021·JAC-antimicrobial Resistance·Katie L HeardStephen Hughes