Antibacterial Activity and Cytotoxicity of Silver(I) Complexes of Pyridine and (Benz)Imidazole Derivatives. X-ray Crystal Structure of [Ag(2,6-di(CH2OH)py)2]NO3

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Urszula Kalinowska-LisJustyn Ochocki

Abstract

Selected aspects of the biological activity of a series of six nitrate silver(I) complexes with pyridine and (benz)imidazole derivatives were investigated. The present study evaluated the antibacterial activities of the complexes against three Gram-negative strains: Pseudomonas aeruginosa ATCC 15442, Escherichia coli ATCC 25922 and Proteus hauseri ATCC 13315. The results were compared with those of silver nitrate, a silver sulfadiazine drug and appropriate ligands. The most significant antibacterial properties were exerted by silver(I) complexes containing benzimidazole derivatives. The cytotoxic activity of the complexes was examined against B16 (murine melanoma) and 10T1/2 (murine fibroblasts) cells. All of the tested silver(I) compounds were not toxic to fibroblast cells in concentration inhibited cancer cell (B16) viability by 50%, which ranged between 2.44-28.65 µM. The molecular and crystal structure of silver(I) complex of 2,6-di(hydroxymethyl)pyridine was determined by single-crystal X-ray diffraction analysis. The most important features of the crystal packing and intermolecular non-covalent interactions in the Ag(I) complex were quantified via Hirshfeld surface analysis.

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Citations

Apr 15, 2017·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Lenka V TamayoHeloisa Beraldo
Dec 23, 2016·International Journal of Pharmaceutics·Dhanya DhanyalayamPasquale Longo
Sep 14, 2019·Archives of Physiology and Biochemistry·Ahmet AltayBulent Caglar
May 24, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lidia RadkoJustyn Ochocki
Aug 15, 2018·IET Nanobiotechnology·Rahul S KalhapureJwala Renukuntla
Jul 30, 2019·Journal of Inorganic Biochemistry·Joana AlmeidaAlexandra R Fernandes
Nov 7, 2020·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Dimitris MatiadisMarina Sagnou
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Adesola A AdelekeBernard Omondi
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natalia MiklášováJán Mojžiš

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Software Mentioned

Epoch
CrystalExplorer
MERCURY
GraphPad Prism
SHELXL

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