Antibacterial Activity and Time-kill Kinetics of Positive Enantiomer of α-pinene Against Strains of Staphylococcus aureus and Escherichia coli

Current Topics in Medicinal Chemistry
Leticia de Sousa EduardoSavio Benvindo Ferreira

Abstract

Research on new antimicrobial agents is needed, as more and more microorganisms that cause antibiotic-resistant diseases are emerging commercially. In this group, we can find strains of Staphylococcus aureus and Escherichia coli, which are highly opportunistic species. Faced with this perspective, research using essential oils present in plants is emerging as a therapeutic alternative for the treatment of antimicrobial infections. Many of these oils have, in their composition, monoterpene α-pinene, that shows to have antibacterial activity. The purpose of this research is to evaluate the antimicrobial activity of the positive enantiomer of α-pinene against strains of Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922. The methodologies used were: Disc-diffusion test, broth microdilution and bacterial death kinetics, all of which were standardized by CLSI. As a result, inhibition halos of 11 mm was obtained for the gram-positive strain and 12 mm for the gram-negative strain, both at the same concentration, 160 µl / ml. In addition, it was possible to observe with the death curve that the concentrations (1.25 µl/mL and 2.5 µl/mL of the (+)-α-pinene were able to eliminate the formation of bacterial colonies at one ti...Continue Reading

Citations

Sep 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tayyebeh GhaffariKi Hyun Kim
Jan 10, 2019·Journal of Biomedical Science·Jonatas Rafael de OliveiraLuciane Dias de Oliveira
Nov 20, 2019·Biomolecules·Bahare SalehiJavad Sharifi-Rad
Oct 24, 2020·Natural Product Research·Jefferson Rodrigues NóbregaEdeltrudes de Oliveira Lima
Aug 21, 2020·Current Topics in Medicinal Chemistry·Felipe Lemos Esteves do AmaralSávio Benvindo Ferreira
Aug 9, 2021·Phytochemistry·Martina Allenspach, Christian Steuer

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