Antibacterial activity of 2',3'-dideoxyadenosine in vivo and in vitro.

Antimicrobial Agents and Chemotherapy
G BeskidR H Geiger

Abstract

2',3'-Dideoxyadenosine (DDA) was shown not only to possess antibacterial activity in vitro against a variety of Enterobacteriaceae, but also to be effective in vivo, DDA was active in experimental mouse infections by the oral route against 5 Salmonella strains, 2 of 3 Arizona strains, 5 of 7 Citrobacter strains, 3 of 8 Klebsiella strains, 3 of 5 Escherichia strains, 1 of 3 Shigella strains, and 3 of 15 Serratia strains at concentrations generally well below the toxic level. Closely related compounds, with the exception of 2',3'-dideoxyinosine, were found to be inactive in vivo, indicating that a high degree of structural specificity was required for activity. The synthesis of deoxyribonucleic acid was inhibited by DDA in those strains susceptible in vitro to DDA, whereas ribonucleic acid and protein syntheses were not affected. The concentration of DDA which inhibited bacterial deoxyribonucleic acid synthesis by 50% was calculated based on the relative rates of deoxyribonucleic acid synthesis in ;the absence and in the presence of DDA. This value correlated well with the minimal inhibitory concentration determined by the in vitro broth dilution assay but not always with in vivo activity determined by the mouse protection test.

References

Nov 30, 1978·Nature·P C van der Vliet, M M Kwant
Jul 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·L Toji, S S Cohen
Sep 1, 1966·Journal of Bacteriology·A M DoeringS S Cohen

❮ Previous
Next ❯

Citations

Aug 26, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·A CatoR Granneman
Jun 1, 1990·Antimicrobial Agents and Chemotherapy·S W MamberS Forenza
Jan 1, 1993·Antimicrobial Agents and Chemotherapy·S J SperberM P Weinstein
Aug 18, 2004·Toxicology and Applied Pharmacology·Miriam C PoirierVernon E Walker

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.