Antibacterial Activity of 7-Epiclusianone and Its Novel Copper Metal Complex on Streptococcus spp. Isolated from Bovine Mastitis and Their Cytotoxicity in MAC-T Cells

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Mariana de BarrosMaria Aparecida S Moreira

Abstract

Mastitis is an inflammation of mammary gland parenchyma that adversely affects bovine health and dairy production worldwide despite significant efforts to eradicate it. The aim of this work was to characterize the antimicrobial activity of 7-epiclusianone (7-epi), a compound extracted from the Rheedia brasiliensis fruit, its complex with copper against Streptococcus spp. isolated from bovine mastitis, and to assess their cytotoxicity to bovine mammary alveolar cells (MAC-T). The complex 7-epiclusianone-Cu (7-epi-Cu) was an amorphous green solid with optical activity. Its vibrational spectrum in the infrared region showed absorption bands in the high-frequency region, as well as bands that can be attributed to the unconjugated and conjugated stretching of the free ligand. The complex was anhydrous. One of the tested bacterial strains was not sensitive to the compounds, while the other three had MIC values of 7.8 µg mL(-1) and minimum bactericidal concentration (MBC) values between 15.6 and 31.3 µg mL(-1). These two compounds are bacteriostatic, did not cause damage to the cell wall and, at sub-inhibitory concentrations, did not induce bacterial adhesion. The compounds were not cytotoxic. Based on these results, 7-epi and 7-epi-C...Continue Reading

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Citations

Dec 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wesley F TaylorEhsan Jabbarzadeh
Feb 24, 2021·Computational Biology and Chemistry·Dayana A RodriguesMarcelo H Dos Santos
Aug 8, 2021·Microorganisms·Tina KabelitzMarcus Fulde
Jul 8, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Simone da Silva Lamartine-HanemannMarisa Ionta

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Methods Mentioned

BETA
nuclear magnetic resonance
X-ray

Software Mentioned

Excel
Agri
SASM

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