Antibacterial activity of a new, stable, aqueous extract of allicin against methicillin-resistant Staphylococcus aureus

British Journal of Biomedical Science
R R Cutler, P Wilson

Abstract

The increasing prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in hospitals and the community has led to a demand for new agents that could be used to decrease the spread of these bacteria. Topical agents such as mupirocin have been used to reduce nasal carriage and spread and to treat skin infections; however, resistance to mupirocin in MRSAs is increasing. Allicin is the main antibacterial agent isolated from garlic, but natural extracts can be unstable. In this study, a new, stable, aqueous extract of allicin (extracted from garlic) is tested on 30 clinical isolates of MRSA that show a range of susceptibilities to mupirocin. Strains were tested using agar diffusion tests, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Diffusion tests showed that allicin liquids produced zone diameters >33 mm when the proposed therapeutic concentration of 500 microg/mL (0.0005% w/v) was used. The selection of this concentration was based on evidence from the MIC, MBC and agar diffusion tests in this study. Of the strains tested, 88% had MICs for allicin liquids of 16 microg/mL, and all strains were inhibited at 32 microg/mL. Furthermore, 88% of clinical isolates had MBCs of 128 microg/mL,...Continue Reading

Citations

Oct 13, 2005·Expert Opinion on Pharmacotherapy·Michael J Sladden, Graham A Johnston
May 3, 2007·Journal of Medicinal Food·Noori S Al-WailiKarem Al-Sahlani
Mar 19, 2014·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Rebecca SnowdenJeffrey Langland
Aug 26, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jan BorlinghausAlan J Slusarenko
Jun 15, 2016·International Journal of Environmental Research and Public Health·Soo Hyeon HongKi Sun Yoon
Nov 13, 2008·The Journal of Antimicrobial Chemotherapy·Ronald R CutlerMartino Dall'Antonia
Sep 29, 2005·Antimicrobial Agents and Chemotherapy·Urs A OchsnerIan A Critchley
Nov 21, 2008·Critical Care Medicine·Luis H Toledo-PereyraFernando Lopez-Neblina
Mar 28, 2020·Nutrients·Gaber El-Saber BatihaHari Prasad Devkota
Apr 16, 2020·The Journal of International Medical Research·Xing-Yang Zhu, Yi-Rong Zeng
Nov 13, 2004·Current Infectious Disease Reports·Philip M Polgreen, Loreen A Herwaldt
Mar 31, 2011·The Angle Orthodontist·Heon-Jin LeeSu-Hyung Hong
May 3, 2007·Journal of Medicinal Food·Ali AydinBariş Bingöl
Mar 25, 2016·The Journal of Biological Chemistry·Alexandra MüllerLars Ingo Ole Leichert
Jan 2, 2016·Journal of Evidence-based Complementary & Alternative Medicine·Masoud Foroutan-RadShahram Khademvatan
Oct 13, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jana ReiterAlan J Slusarenko
Jun 11, 2015·Jundishapur Journal of Microbiology·Guoliang LiChaofeng Sun
Mar 31, 2016·PLoS Neglected Tropical Diseases·María J CorralJosé M Alunda
May 5, 2005·Journal of the American Animal Hospital Association·J Scott Weese
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jan BorlinghausAlan J Slusarenko
Aug 17, 2021·Frontiers in Microbiology·Sushma Bagde BhatwalkarRajaneesh Anupam

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