Antibacterial activity of cefuroxime in human bone

Scandinavian Journal of Infectious Diseases
K DornbuschA Lidström

Abstract

Bone samples were taken at orthopaedic surgery from 12 patients, who had been treated with 2 doses of 750 mg cefuroxime by intravenous infusion. After grinding, extraction and assay by the agar diffusion method the levels of cefuroxime ranged between 0.4--1.9 micrograms/g bone. Using an electrophoretic method followed by microbiological assay, higher levels of cefuroxime were measured, possibly because of a diminution in the binding capacity of the bone.

References

Jan 1, 1977·Scandinavian Journal of Infectious Diseases·K Dornbusch
Jan 1, 1977·Scandinavian Journal of Infectious Diseases·A CarlströmA Hagelberg
Mar 1, 1977·The Journal of Antimicrobial Chemotherapy·K DornbuschA Lidström
Aug 1, 1975·Antimicrobial Agents and Chemotherapy·P NicholasS Z Hirschman
Dec 1, 1975·The Surgical Clinics of North America·R E Condon
Feb 1, 1973·Antimicrobial Agents and Chemotherapy·J M KaplanE Snyder
Jan 1, 1968·Antimicrobial Agents and Chemotherapy·M G Soret
May 27, 1961·Lancet·J Charnley

Citations

Jan 1, 1986·Archives of Orthopaedic and Trauma Surgery·J PapadopulosC Capri
Sep 1, 1983·In Vitro·P B GordonV B Hatcher
Dec 7, 2018·PLoS Neglected Tropical Diseases·Jyotsana DixitK Praveen Karanth
Mar 1, 1985·Drug Intelligence & Clinical Pharmacy·T A Tartaglione, R E Polk
Feb 1, 1983·Orthopedics·B R SmithC Bayliff

Related Concepts

Bacterial Infections
Skeletal Bone
Zinacef
Cephalosporanic Acids
Head of Femur
Hip Joint Implantable Prostheses (Device)
Parenteral Infusion
Microbiological Techniques
Surgical Wound Infection

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