Antibacterial activity of cefuroxime in human bone

Scandinavian Journal of Infectious Diseases
K DornbuschA Lidström


Bone samples were taken at orthopaedic surgery from 12 patients, who had been treated with 2 doses of 750 mg cefuroxime by intravenous infusion. After grinding, extraction and assay by the agar diffusion method the levels of cefuroxime ranged between 0.4--1.9 micrograms/g bone. Using an electrophoretic method followed by microbiological assay, higher levels of cefuroxime were measured, possibly because of a diminution in the binding capacity of the bone.


Jan 1, 1977·Scandinavian Journal of Infectious Diseases·K Dornbusch
Jan 1, 1977·Scandinavian Journal of Infectious Diseases·A CarlströmA Hagelberg
Mar 1, 1977·The Journal of Antimicrobial Chemotherapy·K DornbuschA Lidström
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Dec 1, 1975·The Surgical Clinics of North America·R E Condon
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Jan 1, 1986·Archives of Orthopaedic and Trauma Surgery·J PapadopulosC Capri
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Dec 7, 2018·PLoS Neglected Tropical Diseases·Jyotsana DixitK Praveen Karanth
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Related Concepts

Bacterial Infections
Skeletal Bone
Cephalosporanic Acids
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Parenteral Infusion
Microbiological Techniques
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