Antibacterial activity of extracts from plants of central Argentina--isolation of an active principle from Achyrocline satureioides

Planta medica
Mariana B JorayMaría C Carpinella

Abstract

The great increase in bacterial infections is fueling interest in the search for antibacterial products of plant origin. Extracts obtained from 51 native and naturalized plants from central Argentina were therefore evaluated for their IN VITRO inhibitory activity on pathogenic bacteria with the aim of selecting the most active ones as new sources of effective antibiotics. The susceptibility of reference and clinical strains of Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella enterica serovar Enteritidis, and Staphylococcus aureus was determined. Extracts from Achyrocline satureioides, Flourensia oolepis, Lepechinia floribunda, and Lithrea molleoides were the most potent, with MIC and MBC values ranging from 0.006 to 2 and 0.012 to 10 mg/mL, respectively, on both gram-positive and negative bacteria. The antibacterial activity-guided isolation of A. satureioides ethanol extract showed 23-methyl-6-O-desmethylauricepyrone (1) to be the most active compound. This compound showed inhibitory effects against gram-positive bacteria with MIC and MBC values of 0.002 and 0.008 mg/mL, respectively, while on gram-negative strains, the MIC and MBC were 0.062-0.250 and 0.062-0.500 mg/mL, respective...Continue Reading

Citations

Dec 12, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Carina CaseroFélix Machín
Jan 29, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Mariana Belén JorayMaría Cecilia Carpinella
Apr 23, 2013·Physiologia Plantarum·Matthew C CrispinEve Syrkin Wurtele
Mar 24, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jayanta Kumar Patra, Kwang-Hyun Baek
Dec 18, 2014·Journal of Natural Products·Carina CaseroAna Estévez-Braun
Dec 5, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Mariana Belén JorayMaría Cecilia Carpinella
Jan 19, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muhammad Bilal SadiqAnil Kumar Anal
Apr 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ze-Hua LiShao-Lei Luo
Jun 5, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·María Laura GonzálezMaría Cecilia Carpinella
Nov 17, 2015·Chemistry & Biodiversity·María Yolanda Rios
Mar 11, 2017·Phytochemistry·Margarita M Del M BravettiSara M Palacios

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