Antibacterial activity of flavonoids from the stem bark of Erythrina caffra thunb

Phytotherapy Research : PTR
J C ChukwujekwuJ van Staden

Abstract

The antibacterial activity of the stem bark of Erythrina caffra Thunb. was investigated against different bacterial strains. The antibacterial activity was determined by a micro broth dilution assay. Antibacterial compounds were isolated and identified using a Bruker Avance III LPO NMR spectrometer. Four known flavonoids, abyssione-V 4'-O-methyl ether, 6,8-diprenylgenistein, alpinumisoflavone and burttinone, were isolated. All the compounds were active against both Gram-negative and Gram-positive bacteria. The minimum inhibitory concentration values obtained (MIC) ranged from 3.9 μg/mL to 125 μg/mL. This is the first report of antibacterial activity of burttinone and the isolation of these compounds from E. caffra.

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Citations

Jul 5, 2013·Phytotherapy Research : PTR·Barbara RomanoFrancesca Borrelli
Oct 22, 2011·Asian Pacific Journal of Tropical Medicine·Simplice D KarouJacques Simpore
Mar 29, 2014·Natural Product Research·Zelalem Yibralign DestaRunner R T Majinda
Jun 9, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Naglaa S AshmawyNahla Ayoub
Jan 24, 2017·Journal of Natural Products·Stephen S NyandoroMáté Erdélyi
Oct 14, 2018·Journal of Complementary & Integrative Medicine·Naiara Coelho XimenesSilvânia Maria Mendes Vasconcelos
Oct 23, 2018·Phytotherapy Research : PTR·Faegheh FarhadiMilad Iranshahy
Aug 25, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Xingzhi ZhaoHeng Gao
Jun 25, 2016·Beilstein Journal of Organic Chemistry·Lucian G BahrinLucian M Birsa
Sep 13, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ming FangLi Qian
Sep 26, 2019·Frontiers in Pharmacology·Sylvin Benjamin AtebaDieudonné Njamen
Dec 26, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Lijuan HeWeidong Mao
Sep 4, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·María de Jesús González-BúrquezSalvador Fonseca-Coronado
Aug 28, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bin ZhangJingbo Li
May 13, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Bin ZhangHuan-Rong Zhang

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