Abstract
Aqueous extracts of the leaf of Harungana madagascariensis were analysed phytochemically and evaluated for antimicrobial activity against strains of Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Salmonella typhi and Pseudomonas aeruginosa. Glycosides, tannins, saponins, flavonoids and alkaloids were detected in the plant material. B. subtilis, E. coli and S. typhi, but not Ps. aeruginosa, showed susceptibility at MICs of 2.0 and 15.6 mg/mL; and MBCs of 2.0-3.9 mg/mL and 15.6-31.3 mg/mL, respectively, for the cold and hot extracts. Staph. aureus showed susceptibility only to the hot extract. Concentrations of 2.5-10.0 mg/mL of the cold extract killed over 7 log(10) of the test bacterial population within 30-60 min of exposure. The hot extract needed higher concentrations and longer treatment to achieve similar levels of bacterial cell killing. The results provide a rationalization for the traditional use of H. madagascariensis leaf extracts for the treatment of gastrointestinal disorders.
References
Aug 1, 1979·Planta medica·M IevenE Lammens
Sep 1, 1991·Antimicrobial Agents and Chemotherapy·I Odenholt-TornqvistO Cars
Jul 1, 1983·International Journal of Dermatology·N P Wenner, B Safai
Oct 3, 1998·Antimicrobial Agents and Chemotherapy·A L BaltchL H Bopp
Oct 3, 1998·Antimicrobial Agents and Chemotherapy·E LöwdinO Cars
Jul 1, 1961·Plant Physiology·R W Monk, H H Wiebe
Jan 1, 1979·Planta·H Löppert
Citations
May 27, 2011·Archives of Virology·U U NwodoA I Okoh
Mar 19, 2011·Global Public Health·Evelyn M DellGabrielle Smith
Jul 12, 2007·Journal of Ethnobiology and Ethnomedicine·Daniel P KisangauCosam C Joseph
Sep 14, 2010·Journal of Ethnobiology and Ethnomedicine·Kazhila C Chinsembu, Marius Hedimbi
Mar 3, 2007·Chemical & Pharmaceutical Bulletin·Bruno Ndjakou LentaJoseph Donald Connolly
Feb 27, 2013·Annals of Medical and Health Sciences Research·Tc OnwudiweJo Ogamba
Jul 1, 2006·Acta Odontologica Scandinavica·Brice MoulariYann Pellequer
Aug 1, 2006·Drug Metabolism Reviews·Carolien J P van den Bout-van den BeukelDavid M Burger
Mar 29, 2008·Journal of Ethnopharmacology·E O IwalewaO M Daniyan
Dec 5, 2006·Journal of Ethnopharmacology·B Ndjakou LentaB Weniger
Feb 18, 2006·Journal of Ethnopharmacology·B MoulariF Muyard
Mar 19, 2015·Journal of Medicinal Food·Bassey Sunday AntiaUwemedimo Emmanuel Udo
Sep 3, 2016·Journal of Ethnopharmacology·Nillian MukunguJulius Mwangi
Jun 30, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Guo-Ying ZuoQing Zhang
Jun 11, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Uchechukwu U NwodoAnthony I Okoh
Jan 31, 2006·Phytotherapy Research : PTR·Y HoriA Hatai
May 13, 2008·Environmental Health Perspectives·Beti ThompsonElaine M Faustman
Mar 16, 2011·International Journal of Cosmetic Science·M Kanlayavattanakul, N Lourith
Sep 10, 2020·Chinese Medicine·James Kiamba MailuMitchel Otieno Okumu
Mar 13, 2021·Phytochemistry·Ya-Ping HuangZhi-Qi Yin
Feb 28, 2006·Journal of Natural Products·Simeon F KouamM Iqbal Choudhary
Mar 14, 2007·Journal of Natural Products·Simeon F KouamBarbara Schulz