Antibacterial activity of peptides homologous to a loop region in human lactoferrin

FEBS Letters
Edward W OdellRobert W Evans

Abstract

Human lactoferrin contains a 46 residue sequence named lactoferricin H thought to be responsible for its antimicrobial properties. Synthetic peptides HLT1, corresponding to the loop region of human lactoferricin (FQWQR-NMRKVRGPPVS) and HLT2, corresponding to its charged portion (FQWQRNMRKVR), exerted significant antibacterial effects against E. coli serotype O111 strains NCTC 8007 and ML35. The corresponding sequences in native human lactoferrin were shown to adopt a charged helix and hydrophobic tail within the N-lobe remote from the iron binding site. Sequence similarities between lactoferricin and dermaseptin and magainins suggest that lactoferricin may act as an amphipathic alpha helix.

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Citations

Oct 22, 2003·Molecular Immunology·Sebastien Farnaud, Robert W Evans
Oct 25, 2001·Antiviral Research·B W van der StrateD K Meijer
Oct 11, 2003·Biotechnology Advances·A F Kolb
May 25, 2004·Antimicrobial Agents and Chemotherapy·Daniel S ChappleGiuliano Siligardi
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Jun 14, 2005·Medical Hypotheses·Michael P Sherman, Karel Petrak
Mar 10, 2018·International Journal of Molecular Sciences·Sander BekeschusKristian Wende
Feb 20, 2018·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ya HaoJianhua Wang
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May 29, 1999·Antimicrobial Agents and Chemotherapy·R E Hancock, D S Chapple

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