Antibacterial Activity of Subtilosin Alone and Combined with Curcumin, Poly-Lysine and Zinc Lactate Against Listeria monocytogenes Strains

Probiotics and Antimicrobial Proteins
Tahar AmroucheMichael L Chikindas

Abstract

In this paper, the antibacterial effects of the Bacillus amyloliquefaciens-produced bacteriocin subtilosin, both alone and in combination with curcumin, ε-poly-L-lysine (poly-lysine), or zinc lactate, were examined against Listeria monocytogenes. Results indicated that subtilosin inhibits both of the studied bacterial strains, Scott A (wild-type, nisin sensitive) and NR30 (nisin resistant). However, L. monocytogenes Scott A was more sensitive to subtilosin and pure curcumin. In addition, subtilosin was more active at an acidic pH. Subtilosin in combination with encapsulated curcumin displayed partial synergy against L. monocytogenes ScottA. It also had synergistic activity against both L. monocytogenes Scott A and L. monocytogenes NR30 when combined with zinc lactate. Only an additive effect was observed for subtilosin when combined with non-encapsulated curcumin or poly-lysine against the mentioned strains. Thus, using the combination of subtilosin with curcumin, poly-lysine, or zinc lactate, a lower effective dose can be used to control L. monocytogenes infection. Our findings suggest that subtilosin could be used as alternative bacteriocin to nisin, providing an opportunity to use a novel natural and efficacious biopreservat...Continue Reading

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Citations

May 31, 2014·BioMed Research International·Soheil Zorofchian MoghadamtousiKeivan Zandi
Sep 6, 2015·International Journal of Antimicrobial Agents·Veronica L CaveraMichael L Chikindas
Dec 19, 2017·Probiotics and Antimicrobial Proteins·P V ZolotukhinV A Chistyakov
Jun 21, 2014·Genome Announcements·Andrey V KarlyshevMichael L Chikindas
Sep 13, 2020·Probiotics and Antimicrobial Proteins·Poonam Sheoran, Santosh Kumar Tiwari
Jul 15, 2017·Frontiers in Microbiology·Harsh MathurR Paul Ross
Aug 9, 2017·Current Opinion in Biotechnology·Michael L ChikindasLeon Mt Dicks
May 15, 2021·Probiotics and Antimicrobial Proteins·Rachel MahoneyMichael L Chikindas
Jun 17, 2021·Phytotherapy Research : PTR·Khadijeh KhezriAbbas Seyed Zakaryaei
Jun 19, 2021·Journal of the Science of Food and Agriculture·Mohamed E Abd El-HackKhaled A El-Tarabily

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