Antibacterial activity of Thai herbal extracts on acne involved microorganism

Pharmaceutical Biology
P NiyomkamP Panichayupakaranant

Abstract

Ethyl acetate and methanol extracts of 18 Thai medicinal plants were investigated for their antibacterial activity against Propionibacterium acnes, Stapylococcus aureus, and S. epidermidis. Thirteen plant extracts were capable of inhibiting the growth of P. acnes and S. epidermidis, while 14 plant extracts exhibited an inhibitory effect on S. aureus. Based on the broth dilution method, the ethyl acetate extract of Alpinia galanga (L.) Wild. (Zingiberaceae) rhizome showed the strongest antibacterial effect against P. acnes, with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 156.0 and 312.0 microg/mL, respectively. On the basis of bioassay-guided purification, the ethyl acetate extract was isolated to afford the antibacterial active compound, which was identified as 1'-acetoxychavicol acetate (1'-ACA). 1'-ACA had a strong inhibitory effect on P. acnes with MIC and MBC values of 62.0 and 250.0 microg/mL, respectively. Thus, 1'-ACA was used as an indicative marker for standardization of A. galanga extract using high performance liquid chromatography. These results suggest that A. galanga extract could be an interesting agent for further studies on an alternative treatment of acne.

References

Feb 1, 1987·Planta medica·H ItokawaK Takeya
Dec 1, 1985·Planta medica·A M Janssen, J J Scheffer
Sep 4, 2007·Toxicology Letters·Cheryl T CampbellHeather E Kleiner

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Citations

Jan 5, 2014·The Journal of Microbiology·Mi-Sun KangJong-Suk Oh
Mar 13, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Catherine FeuillolayChristine Roques
Sep 17, 2013·Pharmaceutical Biology·A SuedeeP Panichayupakaranant
Jan 18, 2017·Journal of Cosmetic Dermatology·Ram Hari DahalJaisoo Kim
Sep 1, 2017·International Journal of Dermatology·Ariel Eva EberKeyvan Nouri
Jan 1, 2013·3 Biotech·S Ghosh, L Rangan
Jul 20, 2021·Drug Development and Industrial Pharmacy·Kumud SoniVandana Soni
May 11, 2020·Current Pharmaceutical Biotechnology·Santwona DashJayanta Kumar Patra

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