Antibacterial activity of two limonoids from Swietenia mahagoni against multiple-drug-resistant (MDR) bacterial strains.

Journal of Natural Medicines
A K M Shahidur RahmanSatyajit D Sarker

Abstract

Solvent partitioning followed by column chromatography of the MeOH extract of the seeds of Swietenia mahagoni afforded two limonoids, swietenolide (1) and 2-hydroxy-3-O-tigloylswietenolide (2). The compounds were identified by spectroscopic means. The antibacterial activity of these compounds was assessed against eight multiple-drug-resistant bacterial strains (clinical isolates) by the conventional disc diffusion method. While both compounds were active against all test organisms, compound 2 displayed overall more potent activity than compound 1.

Citations

Oct 15, 2013·Pharmacognosy Magazine·Sanjib SahaSatyajit D Sarker
Mar 25, 2014·Natural Products and Bioprospecting·Wei-Ming ZhangMing-Hua Qiu
May 12, 2016·Angewandte Chemie·Chao LvXiaojiang Hao
Jul 1, 2017·3 Biotech·Ramesh SubramaniKlaus-D Feussner
Jul 4, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yun-Peng SunKuo-Hsiung Lee
Aug 13, 2020·Antibiotics·Marta Ferrera-SuanzesMaría Jesús Durán-Peña
Sep 8, 2011·Chemical Reviews·Qin-Gang Tan, Xiao-Dong Luo

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