Antibacterial activity of Zuccagnia punctata Cav. ethanolic extracts

Journal of Ethnopharmacology
I C ZampiniM I Isla

Abstract

The present study was conducted to investigate antibacterial activity of Zuccagnia punctata ethanolic extract against 47 strains of antibiotic-resistant Gram-negative bacteria and to identify bioactive compounds. Inhibition of bacterial growth was investigated using agar diffusion, agar macrodilution, broth microdilution and bioautographic methods. Zuccagnia punctata extract was active against all assayed bacteria (Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterobacter cloacae, Serratia marcescens, Morganella morganii, Acinetobacter baumannii, Pseudomonas aeruginosa, Stenotrophomonas maltophilia) with minimal inhibitory concentration (MIC) values ranging from 25 to 200 microg/mL. Minimal bactericidal concentration (MBC) values were identical or two-fold higher than the corresponding MIC values. Contact bioautography, indicated that Zuccagnia punctata extracts possess one major antibacterial component against Pseudomonas aeruginosa and at least three components against. Klebsiella pneumoniae and Escherichia coli. Activity-guided fractionation of 1he ethanol extract on a silica gel column yielded a compound (2',4'-dihydroxychalcone), which exhibited strong antibacterial activity with MIC values between 0.10 and ...Continue Reading

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Citations

Aug 16, 2011·Natural Product Research·Mukhrizah OthmanKang Nee Ting
Apr 13, 2013·Natural Product Research·Carola Analía TorresAna María Gonzalez
Jun 16, 2011·Marine Drugs·Edra JiménezHugo Peña-Cortés
Dec 23, 2014·TheScientificWorldJournal·C M MattanaA L Laciar
Jun 13, 2009·Natural Product Research·H JiangX Liu
Apr 13, 2011·Journal of Medicinal Food·Tatiana M Souza-MoreiraRosemeire C L R Pietro
Jan 29, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Mariana Belén JorayMaría Cecilia Carpinella
Nov 21, 2007·Journal of Ethnopharmacology·Iris Catiana ZampiniMaría Inés Isla
Apr 29, 2015·European Journal of Medicinal Chemistry·Xiu-Mei LiTong-Cun Zhang
May 24, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·María Belén AgüeroAlejandro Tapia
Mar 1, 2014·Acta Parasitologica·Romina E D'AlmeidaMaría I Isla
Sep 15, 2011·Asian Pacific Journal of Tropical Medicine·Krishnan KannathasanVenugopalan Venkatesalu
Feb 14, 2007·Molecular Nutrition & Food Research·Mugur N Siddaraju, Shylaja M Dharmesh
Nov 18, 2009·Journal of Agricultural and Food Chemistry·María Belén AgüeroAlejandro Tapia
Jun 3, 2021·International Journal of Molecular Sciences·Mauricio OsorioYesseny Vásquez-Martínez

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