Antibacterial and angiogenic chitosan microneedle array patch for promoting wound healing

Bioactive Materials
Junjie ChiYongan Wang

Abstract

A patch with the capability of avoiding wound infection and promoting tissue remolding is of great value for wound healing. In this paper, we develop a biomass chitosan microneedle array (CSMNA) patch integrated with smart responsive drug delivery for promoting wound healing. Chitosan possesses many outstanding features such as the natural antibacterial property and has been widely utilized for wound healing. Besides, the microstructure of microneedles enables the effective delivery of loaded drugs into the target area and avoids the excessive adhesion between the skin and the patch. Also, vascular endothelial growth factor (VEGF) is encapsulated in the micropores of CSMNA by temperature sensitive hydrogel. Therefore, the smart release of the drugs can be controllably realized via the temperature rising induced by the inflammation response at the site of wounds. It is demonstrated that the biomass CSMNA patch can promote inflammatory inhibition, collagen deposition, angiogenesis, and tissue regeneration during the wound closure. Thus, this versatile CSMNA patch is potentially valuable for wound healing in clinical applications.

Citations

Jun 25, 2020·Pharmaceutics·Antonio José GuillotAna Melero
Jul 1, 2020·Advanced Materials·Rezvan JamaledinPooyan Makvandi
Aug 8, 2020·Frontiers in Cell and Developmental Biology·Ayan NurkeshArman Saparov
Dec 11, 2020·Assay and Drug Development Technologies·Jitendra Gupta Vanshita
Jan 3, 2021·International Journal of Biological Macromolecules·Neha DabholkarGautam Singhvi
Nov 11, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Sujin KimJangho Kim
Oct 3, 2020·Bioactive Materials·Ting SuJianliang Shen
Feb 16, 2021·Advanced Healthcare Materials·Mohamadmahdi SamandariAli Tamayol
Sep 4, 2020·Expert Opinion on Drug Delivery·Lindsay BarnumAli Tamayol
Apr 6, 2021·Bioactive Materials·Junjie ChiYuanjin Zhao
Apr 16, 2021·ACS Applied Materials & Interfaces·Hui ZhangYuanjin Zhao
May 29, 2021·Carbohydrate Polymers·Tânia MonizSalette Reis
Jun 27, 2021·Advanced Healthcare Materials·Mojtaba Farahani, Abbas Shafiee
Jun 15, 2021·International Journal of Biological Macromolecules·Srividya GorantlaGautam Singhvi
Jul 27, 2021·Research : a Science Partner Journal·Lingyu SunYuanjin Zhao
Jul 29, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Parisa HeydariShaghayegh Haghjooy Javanmard
Jul 28, 2021·Small·Motaharesadat Hosseini, Abbas Shafiee
Sep 23, 2020·Biomacromolecules·Liwei ZhangRenjun Pei
Jan 15, 2021·ACS Applied Materials & Interfaces·Wanqing WengYuanjin Zhao

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Methods Mentioned

BETA
confocal microscopy

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