Antibacterial and Cytocompatible Nanoengineered Silk-Based Materials for Orthopedic Implants and Tissue Engineering

ACS Applied Materials & Interfaces
Babak MehrjouPaul K Chu

Abstract

Many postsurgical complications stem from bacteria colony formation on the surface of implants, but the usage of antibiotic agents may cause antimicrobial resistance. Therefore, there is a strong demand for biocompatible materials with an intrinsic antibacterial resistance not requiring extraneous chemical agents. In this study, homogeneous nanocones were fabricated by oxygen plasma etching on the surface of natural, biocompatible Bombyx mori silk films. The new hydroxyl bonds formed on the surface of the nanopatterned film by plasma etching increased the surface energy by around 176%. This hydrophilic nanostructure reduced the bacterial attachment by more than 90% for both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria and at the same time improved the proliferation of osteoblast cells by 30%. The nanoengineered substrate and pristine silk were cultured for 6 h with three different bacteria concentrations of 107, 105, and 103 CFU mL-1 and the cell proliferation on the nanopatterned samples was significantly higher due to limited bacteria attachment and prevention of biofilm formation. The concept and materials described here reveal a promising alternative to produce biomaterials with an inh...Continue Reading

References

Feb 4, 2003·Nature Reviews. Drug Discovery·David Davies
Dec 21, 2005·Biomaterials·Davide CampocciaCarla Renata Arciola
May 12, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Biman B MandalS C Kundu
Jul 31, 2010·Science·Fiorenzo G Omenetto, David L Kaplan
Jul 20, 2011·Biophysical Journal·Hongyuan JiangSean X Sun
Oct 1, 2011·Nature Protocols·Danielle N RockwoodDavid L Kaplan
Oct 21, 2011·Biofouling·A BridierF Dubois-Brissonnet
Mar 7, 2012·International Journal of Nanomedicine·Yanhua ZhengJiao Sun
Sep 8, 2012·Future Microbiology·Thien-Fah Mah
Feb 28, 2013·Biophysical Journal·Sergey PogodinElena P Ivanova
Aug 10, 2013·Soft Matter·Hannah H Tuson, Douglas B Weibel
Aug 21, 2013·Biomaterials·Davide CampocciaCarla Renata Arciola
Nov 28, 2013·Nature Communications·Elena P IvanovaRussell J Crawford
Jan 15, 2014·Acta Biomaterialia·D ArcosM Vallet-Regí
Mar 7, 2014·Nature Communications·Gabriel S PerroneDavid L Kaplan
Oct 5, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Solmaz Maleki DizajKhosro Adibkia
Dec 30, 2014·ACS Applied Materials & Interfaces·Martina LorenzettiSaša Novak
Jan 7, 2015·ACS Applied Materials & Interfaces·Sohee KimMyung Yung Jeong
Mar 19, 2015·Biomedical Materials·Luyuan YangJian R Lu
Jun 17, 2015·Biointerphases·Mary Nora DicksonAlbert F Yee
Sep 8, 2015·Journal of Theoretical Biology·Fudong XueQianzhong Li
Sep 16, 2015·Nanoscale·Jafar Hasan, Kaushik Chatterjee
Sep 26, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Adrian B LiDavid L Kaplan
Dec 15, 2015·Physical Chemistry Chemical Physics : PCCP·Xinlei Li
Feb 13, 2016·Microbiology and Molecular Biology Reviews : MMBR·Desirée C YangNina R Salama
Apr 18, 2016·Advances in Colloid and Interface Science·Zhiwu HanLuquan Ren
Jun 15, 2016·Physical Review. E·Xinlei Li, Tongsheng Chen
Aug 6, 2016·ACS Applied Materials & Interfaces·Vy T H PhamElena P Ivanova
Sep 7, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Marta RibeiroHaritz Sardon
Jun 11, 2017·Journal of Tissue Engineering and Regenerative Medicine·Emily A GosselinDavid L Kaplan
Jul 22, 2017·Journal of Colloid and Interface Science·Aaron ElbourneElena P Ivanova
Aug 3, 2017·MethodsX·Chenlong ZhangJoshua M Pearce
Aug 7, 2017·Advances in Colloid and Interface Science·Abinash TripathyWuge H Briscoe
Sep 25, 2017·Acta Biomaterialia·Promita BhattacharjeeSubhas C Kundu
Apr 1, 2018·Advanced Materials·Geng ChenXiaodong Chen
Jun 8, 2018·Advanced Science·Serena RigoCornelia G Palivan
Jun 11, 2019·ACS Applied Materials & Interfaces·Mehran GhasemlouBenu Adhikari
Oct 9, 2017·ACS Biomaterials Science & Engineering·Irina DrachukNancy Kelley-Loughnane

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