Antibacterial and DNA interaction studies of zinc(II) complexes with quinolone family member, ciprofloxacin

European Journal of Medicinal Chemistry
M N PatelPradhuman Parmar

Abstract

DNA binding and cleavage characteristics of Zn(II) complexes have been investigated. The DNA interaction property of the complexes has been investigated using absorption spectra, viscosity measurements, as well as gel electrophoresis studies. Intrinsic binding constant (K(b)) has been estimated under similar set of experimental conditions. Absorption spectral study indicate that the Zn(II) complexes intercalate between the base pairs of the DNA tightly with intrinsic binding constant in the range of 1.0 x 10(4)-4.0 x 10(4)M(-1) in phosphate buffer. The proposed DNA binding mode supports the large enhancement in the relative viscosity of DNA on binding. The antimicrobial activity of all the ligands and metal complexes has been examined by minimum inhibitory concentration method (MIC).

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Citations

Dec 31, 2014·Applied Biochemistry and Biotechnology·Anamika DebnathDhanraj T Masram
Sep 16, 2016·Journal of Biomolecular Structure & Dynamics·Khyati P ThakorMohan N Patel
Aug 16, 2014·Journal of Hazardous Materials·Rong ZhangLi-Ping Yu
Feb 13, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Suman Kumar TripathySrikanta Patra
Dec 1, 2017·Nucleosides, Nucleotides & Nucleic Acids·Nahid ShahabadiMryam Mahdavi
Feb 28, 2020·FEMS Microbiology Letters·Michiel VosUli Klümper
Dec 22, 2020·Journal of Inorganic Biochemistry·Filipa Ramilo-GomesIsabel Correia

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