Antibacterial and neutralizing effect of human β-defensins on Enterococcus faecalis and Enterococcus faecalis lipoteichoic acid

Journal of Endodontics
Sung-Hoon Lee, Dong-Heon Baek

Abstract

Enterococcus faecalis is frequently found in the root canal of teeth, is a major microorganism of endodontic therapy failure, and is associated with chronic apical periodontitis. Human β-defensins (HBDs) are known to play critical roles in defending the host against infectious microbes and producing dental pulp in healthy and patients. The purpose of the present study was to investigate the bactericidal and neutralizing effects of HBDs on E. faecalis and E. faecalis lipoteichoic acid (Ef LTA) as a major virulence factor of E. faecalis. HBD-1, -2, -3, and -4 were synthesized and investigated the susceptibility against E. faecalis. Also, the neutralizing effects of HBDs on cytokine and intercellular adhesion molecule 1 (ICAM-1) expression by activity of E. faecalis and Ef LTA were analyzed using enzyme-linked immunosorbent assay and flow cytometry. HBD-1 and -2 were weakly susceptible, and HBD-3 and HBD-4 were strongly susceptible to E. faecalis. All of the HBDs exhibited neutralizing effects on the activity of Ef LTA, and HBD-3 strongly neutralized the activity of E. faecalis in tumor necrosis factor-α, interleukin-8, and ICAM-1 expression. The neutralizing effects of HBDs were to inhibit E. faecalis or Ef LTA binding to the hos...Continue Reading

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Citations

Nov 6, 2015·Mediators of Inflammation·Jean-Christophe FargesPaul R Cooper
Mar 30, 2013·Biochemical and Biophysical Research Communications·Akihiro WadaYoshio Ichinose
Mar 9, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Raffaela PeroOlga Scudiero
Jan 26, 2018·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·T C TrichesM M R Cordeiro
Apr 1, 2014·The Journal of Microbiology·Morris O MakobongoD Scott Merrell
Mar 4, 2020·Current Topics in Medicinal Chemistry·Jiarui LiEster Boix
Mar 6, 2019·Restorative Dentistry & Endodontics·Yeon-Jee YooKee-Yeon Kum
Jun 11, 2019·Tissue Engineering. Part B, Reviews·Karim M Fawzy El-SayedChristof E Dörfer
Sep 26, 2020·Frontiers in Physiology·Yue ZhaiYuanyuan Wang
Sep 21, 2020·Journal of Endodontics·Fionnuala T LundyIkhlas A El Karim
Mar 16, 2021·Molecular Oral Microbiology·John Yun NiuChun Hung Chu
Apr 25, 2013·Journal of Endodontics·Yaguang TianZhengmei Lin
Nov 19, 2013·Journal of Endodontics·Jin-Kyung LeeKee-Yeon Kum

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