Antibacterial and synergistic effects of Smallanthus sonchifolius leaf extracts against methicillin-resistant Staphylococcus aureus under light intensity.

Journal of Natural Medicines
Hee JoungDong-Won Shin

Abstract

Smallanthus sonchifolius (yacon) is a perennial plant mostly cultivated in South America, primarily for use of the tubers as a food crop and the leaves as fodder for livestock. The antibacterial activities of the methanol extract of yacon leaves (S. sonchifolius) and its n-hexane, ethyl acetate, n-butanol and water fractions were evaluated against 6 strains of methicillin-resistant Staphylococcus aureus (MRSA) and 1 standard methicillin-susceptible S. aureus (MSSA) strain by using the disc diffusion method and minimal inhibitory concentrations (MICs) assay in the presence and absence of light. No activity was detected when the two methods were performed without light; however, under illumination at 4000 lux, the n-hexane fraction of yacon (HFY) had a MIC of 15.6 microg/ml. HFYL, prepared by exposure of HFY to 4000 lux for 18 h, was more effective than HFY in terms of antimicrobial activity against the 6 MRSA strains and 1 standard MSSA strain. HFYL mixed with ampicillin or oxacillin showed a synergistic effect with all fractional inhibitory concentrations values being below 0.5. The present study demonstrates the enhancement and antimicrobial activity of yacon leaves against MRSA in the presence of light.

References

Oct 8, 1999·The Journal of Antimicrobial Chemotherapy·W Witte
Feb 13, 2001·Journal of Ethnopharmacology·N A AliU Lindequist
Feb 21, 2003·European Journal of Nutrition·Katerina ValentovaVilim Simanek
Oct 31, 2003·Bioscience, Biotechnology, and Biochemistry·Fengqiu LinOsamu Kodama
Jul 10, 2004·Cell Biology and Toxicology·K ValentováJ Ulrichová
Apr 2, 2005·Biological & Pharmaceutical Bulletin·Kaushiki MazumdarSujata Ghosh Dastidar

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Citations

May 28, 2013·Plant Foods for Human Nutrition·Grethel Teresa Choque DelgadoGlaucia Maria Pastore
Sep 25, 2012·Journal of Ethnopharmacology·Carolina Serra BarcellonaSusana Beatriz Genta
Aug 24, 2013·Anais Da Academia Brasileira De Ciências·Isabela K R AgraEmiliano Barreto

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