Antibacterial and wound healing analysis of gelatin/zeolite scaffolds

Colloids and Surfaces. B, Biointerfaces
Neethu NinanYves Grohens

Abstract

In this article, gelatin/copper activated faujasites (CAF) composite scaffolds were fabricated by lyophilisation technique for promoting partial thickness wound healing. The optimised scaffold with 0.5% (w/w) of CAF, G (0.5%), demonstrated pore size in the range of 10-350 μm. Agar disc diffusion tests verified the antibacterial role of G (0.5%) and further supported that bacterial lysis was due to copper released from the core of CAF embedded in the gelatin matrix. The change in morphology of bacteria as a function of CAF content in gelatin scaffold was studied using SEM analysis. The confocal images revealed the increase in mortality rate of bacteria with increase in concentration of incorporated CAF in gelatin matrix. Proficient oxygen supply to needy cells is a continuing hurdle faced by tissue engineering scaffolds. The dissolved oxygen measurements revealed that CAF embedded in the scaffold were capable of increasing oxygen supply and thereby promote cell proliferation. Also, G (0.5%) exhibited highest cell viability on NIH 3T3 fibroblast cells which was mainly attributed to the highly porous architecture and its ability to enhance oxygen supply to cells. In vivo studies conducted on Sprague Dawley rats revealed the abilit...Continue Reading

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Citations

Apr 12, 2014·Carbohydrate Polymers·Mohammad SoheilmoghaddamAbdirahman Ali Yussuf
Dec 17, 2014·Advanced Drug Delivery Reviews·Neethu NinanYves Grohens
Mar 12, 2015·Biochemical and Biophysical Research Communications·Yong LiZheng Guo
Oct 30, 2016·Therapeutic Delivery·Sanjeev RanjanHélder A Santos
Mar 7, 2017·International Wound Journal·Calver PangPatrizia Ferretti
Jul 13, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Azizeh Rahmani Del BakhshayeshAzadeh Montaseri
Apr 10, 2018·Biomaterials Science·Lucie BacakovaIvan Jirka
Jun 26, 2018·Journal of Materials Science. Materials in Medicine·Huan WangYi Lu
Jan 27, 2019·Applied Biochemistry and Biotechnology·Suruchi PoddarSanjeev Kumar Mahto
Mar 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yiu-Jiuan LinHong-Ru Lin
Apr 27, 2021·Water, Air, and Soil Pollution·Paula de Freitas Rosa RemiroMônica Lopes Aguiar

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